ERVW-1

Gene Symbol	ERVW-1
Entrez Gene	30816
Alt Symbol	ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV
Species	Human
Gene Type	protein-coding
Description	endogenous retrovirus group W, member 1
Other Description	HERV-7q envelope protein|HERV-W Env glycoprotein|HERV-W envelope protein|HERV-W_7q21.2 provirus ancestral Env polyprotein|HERV-W{7q21.1} provirus ancestral Env polyprotein|HERV-tryptophan envelope protein|endogenous retroviral family W, env(C7), member 1|endogenous retrovirus group W member 1|env-W|envelope glycoprotein|envelope polyprotein gPr73|envelope protein|enverin|human endogenous retrovirus W envC7-1 envelope protein|syncytin A|syncytin-1
Swissprots	B2RPD4 Q8NHY7 Q9UQF0 Q9NZG3 O95245 O95244 Q9NRZ2
Accessions	AAF74215 AAL11493 AAL11494 AAL11495 AAM68161 AAM68162 AAM68163 AAM68164 AAQ17561 AAQ17562 AAQ17563 AAQ17564 AAQ17565 AAQ17566 AAQ17567 AAQ17568 AAQ17569 AAQ17570 AAQ17571 AAQ17572 AAQ17573 AAQ17574 AAQ17575 AAQ17576 AAQ17577 AAQ17578 AAQ17579 AAQ17580 AAQ17581 AAQ17582 AAQ17583 AAQ17584 AAQ17585 AAQ17586 AAQ17587 AAQ17588 AAQ17589 AAQ17590 AAQ17591 AAQ17592 AAQ17593 AAQ17594 AAQ17595 AAQ17596 AAQ17597 AAQ17598 AAQ17599 AAQ17600 AAQ17601 AAQ17602 AAQ17603 AAQ17604 BAB47558 Q9UQF0 AF072503 AF072505 AAD14545 AF072506 AAD14546 AF072507 AAD14547 AF072508 AAD14548 AF208161 AAF28334 AF506835 AAM33413 AF513360 AAM47599 BC137381 AAI37382 BG012022 BX365066 BX391741 GQ919057 ACX53625 NM_001130925 NP_001124397 NM_014590 NP_055405
Function	This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904). {ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:12050356, ECO:0000269|PubMed:23492904}.
Subcellular Location	Syncytin-1: Virion {ECO:0000250}.
Tissue Specificity	Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia. {ECO:0000269|PubMed:10693809, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:12970426, ECO:0000269|PubMed:15452578}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active SARS E protein fragment - ab48949 from Abcam Category Protein Prices $192.00 Sizes 100 µg Source E. coli

Active West Nile Virus (E protein) protein fragment - ab48960 from Abcam Category Protein Prices $195.00 Sizes 100 µg Source E. coli

AMARV GP protein fragment - ab190126 from Abcam Category Protein Prices $876.00 Sizes 100 µg Source Baculovirus infected sf9 cells

HIV gp41 L peptide - ab43148 from Abcam Category Peptide Prices $290.00 Sizes 500 µg

HIV gp41 L protein fragment - ab49071 from Abcam Category Protein Prices $192.00 Sizes 100 µg Source E. coli

HIV1 gp41 full length protein - ab68935 from Abcam Category Protein Prices $192.00 Sizes 50 µg Source E. coli

HIV1 gp41 protein fragment - ab49068 from Abcam Category Protein Prices $192.00 Sizes 100 µg Source E. coli

HIV1 type O gp41 full length protein - ab68379 from Abcam Category Protein Source E. coli

Human HERV protein fragment - ab162321 from Abcam Category Protein Source Wheat germ Species Human

MARV GP protein fragment - ab190130 from Abcam Category Protein Source Mammalian

SARS E peptide - ab39839 from Abcam Category Peptide

West Nile Virus (E protein) peptide - ab39903 from Abcam Category Peptide

West Nile Virus (E protein) peptide - ab39902 from Abcam Category Peptide

ERVWE1 / HERV / Synctyin Antibody Blocking Peptide - LS-E4670 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERVWE1 / HERV / Synctyin Antibody Blocking Peptide - LS-E7030 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HERV Protein - H00030816-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HERV Peptide - P1202 from Novus Biologicals Category Peptide Species Human

ERVWE1-Antibody-C-term-Blocking-Peptide - BP17034b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HERV-ERVWE1-Antibody-Center-Blocking-peptide - BP2716c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Envelope glycoprotein peptide - orb72647 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

ERVWE1 Blocking Peptide - 33R-9252 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

West Nile Virus E protein (His tag) - 80-1339 from Fitzgerald Category Protein Prices $195.00, $945.00 Sizes 100 µg, 1 mg Source E.coli

ERVWE1 - H00030816-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ERVWE1 - H00030816-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ERVWE1 fusion protein - ag19227 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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