| Gene Symbol |
TAOK1
|
| Entrez Gene |
57551
|
| Alt Symbol |
KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAOK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TAO kinase 1
|
| Other Description |
MARK Kinase|STE20-like kinase PSK2|kinase from chicken homolog B|microtubule affinity regulating kinase kinase|prostate-derived STE20-like kinase 2|prostate-derived sterile 20-like kinase 2|serine/threonine protein kinase TAO1 homolog|serine/threonine-protein kinase TAO1|thousand and one amino acid protein 1|thousand and one amino acid protein kinase 1
|
| Swissprots |
A2RUT8 Q7L7X3 Q96L75 Q9H2K7 B7ZLV6 Q9P2I6 Q9H7S5
|
| Accessions |
CAH05616 EAW51188 EAW51189 EAW51190 Q7L7X3 AB037782 BAA92599 AF263312 AAG38502 AK024376 BAB14901 AK025902 AL110163 AL833649 AY049015 AAL12217 BC024166 BC032793 BC037535 BC037740 BC047652 BC051737 BC062764 BC133039 AAI33040 BC144067 AAI44068 BE772351 CA395289 CK300429 XM_011525060 XP_011523362 NM_020791 NP_065842 NM_025142 NP_079418
|
| Function |
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:13679851}.
|
| Tissue Specificity |
Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle. {ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:9786855}.
|
| Top Pathways |
MAPK signaling pathway
|