TAOK1

Gene Symbol TAOK1
Entrez Gene 57551
Alt Symbol KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAOK1
Species Human
Gene Type protein-coding
Description TAO kinase 1
Other Description MARK Kinase|STE20-like kinase PSK2|kinase from chicken homolog B|microtubule affinity regulating kinase kinase|prostate-derived STE20-like kinase 2|prostate-derived sterile 20-like kinase 2|serine/threonine protein kinase TAO1 homolog|serine/threonine-protein kinase TAO1|thousand and one amino acid protein 1|thousand and one amino acid protein kinase 1
Swissprots A2RUT8 Q7L7X3 Q96L75 Q9H2K7 B7ZLV6 Q9P2I6 Q9H7S5
Accessions CAH05616 EAW51188 EAW51189 EAW51190 Q7L7X3 AB037782 BAA92599 AF263312 AAG38502 AK024376 BAB14901 AK025902 AL110163 AL833649 AY049015 AAL12217 BC024166 BC032793 BC037535 BC037740 BC047652 BC051737 BC062764 BC133039 AAI33040 BC144067 AAI44068 BE772351 CA395289 CK300429 XM_011525060 XP_011523362 NM_020791 NP_065842 NM_025142 NP_079418
Function Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies
Subcellular Location Cytoplasm {ECO:0000269|PubMed:13679851}.
Tissue Specificity Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle. {ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:9786855}.
Top Pathways MAPK signaling pathway

PSK2 (D-20) - sc-83463 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PSK2 (E-12) - sc-83464 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PSK2 (T-25) - sc-130857 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PSK2 (T-25): sc-130857. Western blot analysis of PSK2 expression in mouse brain tissue extract.

Anti-TAOK1 antibody - ab92601 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TAOK1 antibody (ab92601) at 1/500 dilutionLane 1 : NIH/3T3 cell lysate with absence of blocking peptideLane 2 : NIH/3T3 cell lysate with presence of blocking peptide (10 µg)Lysates/proteins at 30 µg per lane.

Anti-TAOK1 antibody - ab52097 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 antibody - ab101607 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab101607 at 5 µg/ml staining TAOK1 in Human cortex by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-TAOK1 antibody - ab57529 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TAOK1 antibody [EPR12908(2)] - ab197891 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12908(2)
All lanes : Anti-TAOK1 antibody [EPR12908(2)] (ab197891) at 1/1000 dilutionLane 1 : Human seminoma lysateLane 2 : Human testis lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-TAOK1 / TAO1 Antibody - LS-C48699 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 / TAO1 Antibody - LS-C146952 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 / TAO1 Antibody (Internal, AP) - LS-C246086 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 / TAO1 Antibody (Internal, APC) - LS-C246087 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 / TAO1 Antibody (Internal, FITC) - LS-C246089 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 / TAO1 Antibody (Internal, Biotin) - LS-C246088 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 / TAO1 Antibody (Internal, PE) - LS-C246094 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 / TAO1 Antibody (Internal, Azide-free, HRP) - LS-C247914 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 / TAO1 Antibody (aa620-650) - LS-C98040 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-TAOK1 antibody in mouse brain tissue lysate (35 ug/lane). TAOK1(arrow) was detected using the purified antibody.

Anti-TAOK1 / TAO1 Antibody (Internal) - LS-C330685 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 / TAO1 Antibody (aa400-450) - LS-C287409 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK1 / TAO1 Antibody (Internal) - LS-C345303 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of TAOK1 Antibody with HepG2 Whole Cell lysate.

Anti-TAOK1 / TAO1 Antibody (clone 4E12) - LS-C133800 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E12
Immunoperoxidase of monoclonal antibody to TAOK1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]

Anti-TAOK1 / TAO1 Antibody (aa431-480) IHC-plus™ - LS-B8589 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TAO1 / TAOK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8589 dilution 5 ug/ml.

Anti-TAOK1 / TAO1 Antibody (C-Terminus) IHC-plus™ - LS-A7008 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TAOK1 antibody LS-A7008 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TAOK1 / TAO1 Antibody (Internal) IHC-plus™ - LS-A7971 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TAOK1 antibody LS-A7971 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TAOK1 / TAO1 Antibody (Internal) IHC-plus™ - LS-A6871 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TAOK1 antibody LS-A6871 IHC of human brain, hippocampus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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