TAOK1

Gene Symbol	TAOK1
Entrez Gene	57551
Alt Symbol	KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAOK1
Species	Human
Gene Type	protein-coding
Description	TAO kinase 1
Other Description	MARK Kinase|STE20-like kinase PSK2|kinase from chicken homolog B|microtubule affinity regulating kinase kinase|prostate-derived STE20-like kinase 2|prostate-derived sterile 20-like kinase 2|serine/threonine protein kinase TAO1 homolog|serine/threonine-protein kinase TAO1|thousand and one amino acid protein 1|thousand and one amino acid protein kinase 1
Swissprots	A2RUT8 Q7L7X3 Q96L75 Q9H2K7 B7ZLV6 Q9P2I6 Q9H7S5
Accessions	CAH05616 EAW51188 EAW51189 EAW51190 Q7L7X3 AB037782 BAA92599 AF263312 AAG38502 AK024376 BAB14901 AK025902 AL110163 AL833649 AY049015 AAL12217 BC024166 BC032793 BC037535 BC037740 BC047652 BC051737 BC062764 BC133039 AAI33040 BC144067 AAI44068 BE772351 CA395289 CK300429 XM_011525060 XP_011523362 NM_020791 NP_065842 NM_025142 NP_079418
Function	Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:13679851}.
Tissue Specificity	Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle. {ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:9786855}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TAOK1 protein fragment - ab63169 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human TAOK1 protein fragment - ab153456 from Abcam Category Protein Source Wheat germ Species Human

TAOK1 / TAO1 Antibody Blocking Peptide - LS-E8675 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TAOK1 / TAO1 Antibody Blocking Peptide - LS-E29199 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TAOK1 / TAO1 Antibody Blocking Peptide - LS-E29213 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TAOK1 / TAO1 Antibody Blocking Peptide - LS-E29299 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human TAO Kinase 1 Protein - H00057551-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TAO Kinase 1 Peptide - P2210 from Novus Biologicals Category Peptide Species Human

TAOK1-Antibody-Center-Blocking-Peptide - BP7085c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TAOK1 Blocking Peptide - 33R-10914 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

TAO Kinase 1 (TAOK1) - H00057551-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TAO Kinase 1 (TAOK1) - H00057551-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human TAO Kinase 1, GST-tagged, Active - TAOK1-441H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

TAO1 Protein, active, 10 µg - 14-749 from EMD Millipore Category Protein Prices $315.00 Sizes 10 µg Source Expressed by baculovirus in Sf21 cells.

TAO1 Protein, active, 250 µg - 14-749M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-749) and in bulk (cat# 14-749-K) Source Expressed by baculovirus in Sf21 cells.

Recombinant Human Serine/threonine-protein kinase TAO1(TAOK1) ,partial - CSB-YP752101HU CSB-EP752101HU CSB-BP752101HU CSB-MP752101HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TAOK1 Blocking Peptide - 3776RBP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

TAOK1 fusion protein - Ag22461 from Proteintech Group Category Protein Species Human

TAOK1, Peptide - MBS843707 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

TAO Kinase 1 Recombinant Protein Antigen - NBP1-89864PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TAOK1-TAO1-Antibody-Center-Blocking-peptide - BP7969c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TAOK1 Peptide, Human - M34GP15573H from Creative Peptides Category Peptide Source Synthetic. Species Human

TAO1 Blocking Peptide - CBP4843 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Serine/threonine-protein kinase TAO1 (TAOK1), partial, Recombinant Protein - MBS1294125 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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