| Gene Symbol |
SSC5D
|
| Entrez Gene |
284297
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
scavenger receptor cysteine rich family, 5 domains
|
| Other Description |
scavenger receptor cysteine rich domain containing (5 domains)|scavenger receptor cysteine-rich glycoprotein|soluble scavenger protein with 5 SRCR domains|soluble scavenger receptor cysteine-rich domain-containing protein SSC5D|soluble scavenger with 5 domains
|
| Swissprots |
K7EP70 B5MDQ5 C7S7U0 A1L4H1 C7S7T9
|
| Accessions |
A1L4H1 AF086519 AK092577 BAC03917 BC130538 AAI30539 BC130540 AAI30541 DA008417 EU699476 ACJ02751 EU699477 ACJ02752 XM_011526758 XP_011525060 XM_011526759 XP_011525061 NM_182571 NM_001144950 NP_001138422 NM_001195267 NP_001182196
|
| Function |
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in monocytes/macrophages and T-lymphocytes. Highly expressed in placenta and spleen, and also detected at lower levels in colon, and more weakly in lung, heart and kidney. {ECO:0000269|PubMed:19535143}.
|