Gene Symbol | BRD8 |
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Entrez Gene | 10902 |
Alt Symbol | SMAP, SMAP2, p120 |
Species | Human |
Gene Type | protein-coding |
Description | bromodomain containing 8 |
Other Description | bromodomain-containing protein 8|skeletal muscle abundant protein 2|thyroid hormone receptor coactivating protein of 120 kDa|trCP120 |
Swissprots | O43178 Q58AB0 Q59GN0 Q15355 Q9H0E9 Q969M9 |
Accessions | EAW62159 EAW62160 EAW62161 EAW62162 Q9H0E9 AB209079 BAD92316 AF016270 AAB87858 AK124191 AK225928 AK289951 BAF82640 AK293621 BAG57080 AK297608 BAG59991 AK297756 BAG60105 AK310380 AK312333 BAG35254 AL136823 CAB66757 AL704983 BC008039 AAH08039 BC008076 AAH08076 BU187982 X87613 CAA60949 X94234 CAA63925 XM_005271855 XP_005271912 XM_005271856 XP_005271913 XM_005271857 XP_005271914 XM_005271859 XP_005271916 XM_005271860 XP_005271917 XM_005271861 XP_005271918 XM_005271865 XP_005271922 XM_006714524 XP_006714587 XM_006714525 XP_006714588 XM_011543109 XP_011541411 XM_011543110 XP_011541412 XM_011543111 XP_011541413 XR_948229 XR_948230 NM_001164326 NP_001157798 NM_001300961 NP_001287890 NM_001300962 NP_001287891 NM_001300966 NP_001287895 NM_006696 NP_006687 NM_139199 NP_631938 NM_183359 |
Function | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1- like complex that specifically mediates the remo |
Subcellular Location | Nucleus. |
Tissue Specificity | Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:8611617}. |
Bromodomain-containing protein 8 (BRD8), Human, ELISA Kit - E01B0838 from ARP American Research Products
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Bromodomain containing protein 8 (BRD8), ELISA Kit - MBS7200805 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7237633 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7246342 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7247202 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7225960 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7222634 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7246965 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7251074 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7201422 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7224471 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7211976 from MyBioSource
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Bromodomain-containing protein 8 (BRD8), ELISA Kit - MBS7223795 from MyBioSource
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Human BRD8 ELISA Kit - E005346 from Biobool
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anti-p120 (catenin delta 1) antibody [SP63] - ARG53400 from Arigo Biolaboratories
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anti-p120 (catenin delta 1) antibody - ARG53398 from Arigo Biolaboratories
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anti-p120 (catenin delta 1) antibody [SP63] (Ready-to-Use) - ARG53401 from Arigo Biolaboratories
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anti-p120 (catenin delta 1) antibody (Ready-to-Use) - ARG53399 from Arigo Biolaboratories
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