BRD8

Gene Symbol BRD8
Entrez Gene 10902
Alt Symbol SMAP, SMAP2, p120
Species Human
Gene Type protein-coding
Description bromodomain containing 8
Other Description bromodomain-containing protein 8|skeletal muscle abundant protein 2|thyroid hormone receptor coactivating protein of 120 kDa|trCP120
Swissprots O43178 Q58AB0 Q59GN0 Q15355 Q9H0E9 Q969M9
Accessions EAW62159 EAW62160 EAW62161 EAW62162 Q9H0E9 AB209079 BAD92316 AF016270 AAB87858 AK124191 AK225928 AK289951 BAF82640 AK293621 BAG57080 AK297608 BAG59991 AK297756 BAG60105 AK310380 AK312333 BAG35254 AL136823 CAB66757 AL704983 BC008039 AAH08039 BC008076 AAH08076 BU187982 X87613 CAA60949 X94234 CAA63925 XM_005271855 XP_005271912 XM_005271856 XP_005271913 XM_005271857 XP_005271914 XM_005271859 XP_005271916 XM_005271860 XP_005271917 XM_005271861 XP_005271918 XM_005271865 XP_005271922 XM_006714524 XP_006714587 XM_006714525 XP_006714588 XM_011543109 XP_011541411 XM_011543110 XP_011541412 XM_011543111 XP_011541413 XR_948229 XR_948230 NM_001164326 NP_001157798 NM_001300961 NP_001287890 NM_001300962 NP_001287891 NM_001300966 NP_001287895 NM_006696 NP_006687 NM_139199 NP_631938 NM_183359
Function May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1- like complex that specifically mediates the remo
Subcellular Location Nucleus.
Tissue Specificity Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:8611617}.

BRD8 CRISPR/Cas9 KO Plasmid (h) - sc-408818 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRD8 HDR Plasmid (h) - sc-408818-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRD8 Double Nickase Plasmid (h) - sc-408818-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRD8 Double Nickase Plasmid (h2) - sc-408818-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRD8 CRISPR Activation Plasmid (h) - sc-408818-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRD8 CRISPR Activation Plasmid (h2) - sc-408818-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRD8 Lentiviral Activation Particles (h) - sc-408818-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRD8 Lentiviral Activation Particles (h2) - sc-408818-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRD8 siRNA (h) - sc-92032 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRD8 shRNA Plasmid (h) - sc-92032-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRD8 shRNA (h) Lentiviral Particles - sc-92032-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRD8 RNAi - H00010902-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

BRD8 RNAi - H00010902-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

BRD8 RNAi - H00010902-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU058911 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN4053 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4053 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

BRD8 siRNA (Human) - CRH7431 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BRD8 - MBS8203811 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BRD8 shRNA Plasmid (Human) - CHH7431 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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