Gene Symbol | PLA2G4F |
---|---|
Entrez Gene | 255189 |
Alt Symbol | PLA2G4FZ |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase A2, group IVF |
Other Description | cPLA2-zeta|cytosolic phospholipase A2 zeta |
Swissprots | Q68DD2 Q6ZMC8 |
Accessions | EAW92531 EAW92532 EAW92533 EAW92534 Q68DD2 AK122623 BAG53627 AK172836 BAD18801 AK304368 BAG65207 AL832972 BC035335 AAH35335 BC040920 BC111481 BC131531 AAI31532 BC142682 AAI42683 BC146648 AAI46649 BM986790 CR749451 CAH18288 XR_931785 XR_931786 NM_213600 NP_998765 NR_033151 |
Function | Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytosol. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates to lysosomal membranes in a calcium-dependent fashion. {ECO:0000250}. |
Top Pathways | Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels |