Gene Symbol | PLA2G4F |
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Entrez Gene | 255189 |
Alt Symbol | PLA2G4FZ |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase A2, group IVF |
Other Description | cPLA2-zeta|cytosolic phospholipase A2 zeta |
Swissprots | Q68DD2 Q6ZMC8 |
Accessions | EAW92531 EAW92532 EAW92533 EAW92534 Q68DD2 AK122623 BAG53627 AK172836 BAD18801 AK304368 BAG65207 AL832972 BC035335 AAH35335 BC040920 BC111481 BC131531 AAI31532 BC142682 AAI42683 BC146648 AAI46649 BM986790 CR749451 CAH18288 XR_931785 XR_931786 NM_213600 NP_998765 NR_033151 |
Function | Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytosol. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates to lysosomal membranes in a calcium-dependent fashion. {ECO:0000250}. |
Top Pathways | Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels |
group IVF sPLA 2 CRISPR/Cas9 KO Plasmid (h) - sc-415215 from Santa Cruz Biotechnology
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group IVF sPLA 2 HDR Plasmid (h) - sc-415215-HDR from Santa Cruz Biotechnology
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group IVF sPLA 2 Double Nickase Plasmid (h) - sc-415215-NIC from Santa Cruz Biotechnology
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group IVF sPLA 2 Double Nickase Plasmid (h2) - sc-415215-NIC-2 from Santa Cruz Biotechnology
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group IVF sPLA 2 CRISPR Activation Plasmid (h) - sc-415215-ACT from Santa Cruz Biotechnology
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group IVF sPLA 2 CRISPR Activation Plasmid (h2) - sc-415215-ACT-2 from Santa Cruz Biotechnology
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group IVF sPLA 2 Lentiviral Activation Particles (h) - sc-415215-LAC from Santa Cruz Biotechnology
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group IVF sPLA 2 Lentiviral Activation Particles (h2) - sc-415215-LAC-2 from Santa Cruz Biotechnology
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group IVF sPLA 2 siRNA (h) - sc-90284 from Santa Cruz Biotechnology
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group IVF sPLA 2 shRNA Plasmid (h) - sc-90284-SH from Santa Cruz Biotechnology
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group IVF sPLA 2 shRNA (h) Lentiviral Particles - sc-90284-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU116711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16899 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16899 from Sigma-Aldrich
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PLA2G4F siRNA (Human) - CRJ6710 from Cohesion Biosciences
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shRNA set against Human PLA2 (NM_213600.3) - SHH376652 from Creative biogene
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PLA2G4F shRNA Plasmid (Human) - CHJ6710 from Cohesion Biosciences
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PLA2G4F miRNA 3'UTR clone - MiUTR3H-15725 from Creative biogene
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