| Gene Symbol | PSRC1 |
|---|---|
| Entrez Gene | 84722 |
| Alt Symbol | DDA3, FP3214 |
| Species | Human |
| Gene Type | protein-coding |
| Description | proline/serine-rich coiled-coil 1 |
| Other Description | differential display and activated by p53|p53-regulated DDA3|proline/serine-rich coiled-coil protein 1 |
| Swissprots | Q9BV77 Q5T2Z3 Q6ZTI8 Q71MG3 Q6PGN9 |
| Accessions | AAN73434 EAW56373 EAW56374 EAW56375 EAW56376 EAW56377 Q6PGN9 AF223000 AAN73431 AF447874 AAQ04649 AK126567 BAC86599 AK289593 BAF82282 BC056909 AAH56909 BE206101 BF984061 BI857497 BJ992594 BQ448200 BX649139 HQ448122 ADQ32603 XM_005271283 XP_005271340 XM_006710982 XP_006711045 XM_011542306 XP_011540608 NM_001005290 NP_001005290 NM_001032291 NP_001027462 NM_001032290 NM_032636 NP_116025 |
| Function | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase. |
| Tissue Specificity | Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle. {ECO:0000269|PubMed:12427559}. |