| Gene Symbol | PSRC1 |
|---|---|
| Entrez Gene | 84722 |
| Alt Symbol | DDA3, FP3214 |
| Species | Human |
| Gene Type | protein-coding |
| Description | proline/serine-rich coiled-coil 1 |
| Other Description | differential display and activated by p53|p53-regulated DDA3|proline/serine-rich coiled-coil protein 1 |
| Swissprots | Q9BV77 Q5T2Z3 Q6ZTI8 Q71MG3 Q6PGN9 |
| Accessions | AAN73434 EAW56373 EAW56374 EAW56375 EAW56376 EAW56377 Q6PGN9 AF223000 AAN73431 AF447874 AAQ04649 AK126567 BAC86599 AK289593 BAF82282 BC056909 AAH56909 BE206101 BF984061 BI857497 BJ992594 BQ448200 BX649139 HQ448122 ADQ32603 XM_005271283 XP_005271340 XM_006710982 XP_006711045 XM_011542306 XP_011540608 NM_001005290 NP_001005290 NM_001032291 NP_001027462 NM_001032290 NM_032636 NP_116025 |
| Function | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase. |
| Tissue Specificity | Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle. {ECO:0000269|PubMed:12427559}. |
DDA3 CRISPR/Cas9 KO Plasmid (h) - sc-406941 from Santa Cruz Biotechnology
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DDA3 HDR Plasmid (h) - sc-406941-HDR from Santa Cruz Biotechnology
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DDA3 Double Nickase Plasmid (h) - sc-406941-NIC from Santa Cruz Biotechnology
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DDA3 Double Nickase Plasmid (h2) - sc-406941-NIC-2 from Santa Cruz Biotechnology
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DDA3 CRISPR Activation Plasmid (h) - sc-406941-ACT from Santa Cruz Biotechnology
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DDA3 CRISPR Activation Plasmid (h2) - sc-406941-ACT-2 from Santa Cruz Biotechnology
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DDA3 Lentiviral Activation Particles (h) - sc-406941-LAC from Santa Cruz Biotechnology
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DDA3 Lentiviral Activation Particles (h2) - sc-406941-LAC-2 from Santa Cruz Biotechnology
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DDA3 siRNA (h) - sc-88718 from Santa Cruz Biotechnology
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DDA3 shRNA Plasmid (h) - sc-88718-SH from Santa Cruz Biotechnology
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DDA3 shRNA (h) Lentiviral Particles - sc-88718-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU011231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17643 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17643 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04638 from Sigma-Aldrich
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PSRC1 siRNA (Human) - CRJ3601 from Cohesion Biosciences
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shRNA set against Human PSRC1 (NM_032636.7) - SHH385692 from Creative biogene
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PSRC1 shRNA Plasmid (Human) - CHJ3601 from Cohesion Biosciences
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PSRC1 miRNA 3'UTR clone - MiUTR3H-12749 from Creative biogene
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PSRC1 miRNA 3'UTR clone - MiUTR3H-12750 from Creative biogene
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PSRC1 miRNA 3'UTR clone - MiUTR3H-12751 from Creative biogene
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