Gene Symbol | POLR2I |
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Entrez Gene | 5438 |
Alt Symbol | RPB9, hRPB14.5 |
Species | Human |
Gene Type | protein-coding |
Description | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa |
Other Description | DNA-directed RNA polymerase II 14.5 kDa polypeptide|DNA-directed RNA polymerase II subunit I|DNA-directed RNA polymerase II subunit RPB9|RNA polymerase II 14.5 kDa subunit|RNA polymerase II subunit B9|RPB14.5 |
Swissprots | B2R5J2 Q6NW05 P36954 |
Accessions | AAB51181 CAA80649 P36954 AK312206 BAG35139 BC017112 AAH17112 BC017860 BC067794 AAH67794 DQ893214 ABM84140 DQ896543 ABM87542 NM_006233 NP_006224 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:9852112}. |
Top Pathways | Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |
POLR2I (F-11) - sc-398049 from Santa Cruz Biotechnology
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POLR2I (C-14) - sc-131760 from Santa Cruz Biotechnology
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POLR2I (D-12) - sc-131761 from Santa Cruz Biotechnology
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POLR2I (Q-12) - sc-131763 from Santa Cruz Biotechnology
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POLR2I (H-120) - sc-368669 from Santa Cruz Biotechnology
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Anti-RNA Polymerase II p14.5 antibody - ab180730 from Abcam
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Anti-RNA Polymerase II p14.5 antibody - ab192405 from Abcam
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Anti-RNA Polymerase II p14.5 antibody - ab192407 from Abcam
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Anti-RNA Polymerase II p14.5 antibody - ab57305 from Abcam
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Anti-RNA Polymerase II p14.5 antibody - ab28436 from Abcam
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Anti-POLR2I Antibody (clone 140C1a) - LS-C184767 from LifeSpan Bioscience
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Anti-POLR2I Antibody (Internal) - LS-C209849 from LifeSpan Bioscience
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Anti-POLR2I Antibody (C-Terminus) - LS-C209850 from LifeSpan Bioscience
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Anti-POLR2I Antibody - LS-C340967 from LifeSpan Bioscience
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Anti-POLR2I Antibody - LS-C341365 from LifeSpan Bioscience
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Anti-POLR2I Antibody (N-Terminus) - LS-C80231 from LifeSpan Bioscience
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Anti-POLR2I Antibody (clone 140C1a) - LS-C342790 from LifeSpan Bioscience
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Anti-POLR2I Antibody (clone 2B3) - LS-C197947 from LifeSpan Bioscience
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Anti-POLR2I Antibody (aa38-87) - LS-C80130 from LifeSpan Bioscience
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Anti-POLR2I Antibody - LS-C331738 from LifeSpan Bioscience
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RPB9 Antibody - NBP1-92344 from Novus Biologicals
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RPB9 Antibody (2B3) - H00005438-M01 from Novus Biologicals
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Anti-POLR2I antibody produced in rabbit - HPA045156 from Sigma-Aldrich
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Anti-POLR2I (AB2) antibody produced in rabbit - AV38758 from Sigma-Aldrich
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Anti-POLR2I (AB1) antibody produced in rabbit - AV35790 from Sigma-Aldrich
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