Gene Symbol | POLR2I |
---|---|
Entrez Gene | 5438 |
Alt Symbol | RPB9, hRPB14.5 |
Species | Human |
Gene Type | protein-coding |
Description | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa |
Other Description | DNA-directed RNA polymerase II 14.5 kDa polypeptide|DNA-directed RNA polymerase II subunit I|DNA-directed RNA polymerase II subunit RPB9|RNA polymerase II 14.5 kDa subunit|RNA polymerase II subunit B9|RPB14.5 |
Swissprots | B2R5J2 Q6NW05 P36954 |
Accessions | AAB51181 CAA80649 P36954 AK312206 BAG35139 BC017112 AAH17112 BC017860 BC067794 AAH67794 DQ893214 ABM84140 DQ896543 ABM87542 NM_006233 NP_006224 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:9852112}. |
Top Pathways | Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |
POLR2I CRISPR/Cas9 KO Plasmid (h) - sc-410948 from Santa Cruz Biotechnology
|
||||||||
POLR2I HDR Plasmid (h) - sc-410948-HDR from Santa Cruz Biotechnology
|
||||||||
POLR2I Double Nickase Plasmid (h) - sc-410948-NIC from Santa Cruz Biotechnology
|
||||||||
POLR2I Double Nickase Plasmid (h2) - sc-410948-NIC-2 from Santa Cruz Biotechnology
|
||||||||
POLR2I CRISPR Activation Plasmid (h) - sc-410948-ACT from Santa Cruz Biotechnology
|
||||||||
POLR2I CRISPR Activation Plasmid (h2) - sc-410948-ACT-2 from Santa Cruz Biotechnology
|
||||||||
POLR2I Lentiviral Activation Particles (h) - sc-410948-LAC from Santa Cruz Biotechnology
|
||||||||
POLR2I Lentiviral Activation Particles (h2) - sc-410948-LAC-2 from Santa Cruz Biotechnology
|
||||||||
POLR2I siRNA (h) - sc-97881 from Santa Cruz Biotechnology
|
||||||||
POLR2I shRNA Plasmid (h) - sc-97881-SH from Santa Cruz Biotechnology
|
||||||||
POLR2I shRNA (h) Lentiviral Particles - sc-97881-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU138291 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17119 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17119 from Sigma-Aldrich
|
||||||||
POLR2I siRNA (Human) - CRH3641 from Cohesion Biosciences
|
||||||||
RPB9 RNAi - H00005438-R01 from Novus Biologicals
|
||||||||
shRNA set against Human POLR2I (NM_006233.4) - SHH379472 from Creative biogene
|
||||||||
shRNA set against Human POLR2I(NM_006233.4) - SHR127812 from Creative biogene
|
||||||||
Human POLR2I siRNA - orb264143 from Biorbyt
|
||||||||
POLR2I shRNA Plasmid (Human) - CHH3641 from Cohesion Biosciences
|
||||||||
POLR2I miRNA 3'UTR clone - MiUTR1H-08077 from Creative biogene
|