PRDM6

Gene Symbol PRDM6
Entrez Gene 93166
Alt Symbol -
Species Human
Gene Type protein-coding
Description PR domain containing 6
Other Description PR domain zinc finger protein 6|PR domain-containing protein 6|PR-domain zinc finger protein 6|putative histone-lysine N-methyltransferase PRDM6
Swissprots Q9NQX0 B5MCJ4 Q9NQW9
Accessions Q9NQX0 AF272898 AAF78078 AF272899 AAF78079 AK297992 BAG60300 HG498412 XM_005272128 XP_005272185 XM_011543725 XP_011542027 XM_011543726 XP_011542028 XR_948304 XR_948305 NM_001136239 NP_001129711
Function Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}.

PRDM6 (M-159) - sc-98736 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PRDM6 (M-159): sc-98736. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear and cytoplasmic localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

PRDM6 (K-24) - sc-133924 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
PRDM6 (K-24): sc-133924. Western blot analysis of PRDM6 expression in Jurkat whole cell lysate.

Anti-PRDM6 antibody - ab75211 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PRDM6 antibody (ab75211) at 1 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-PRDM6 antibody - ab123317 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PRDM6 antibody (ab123317) at 1/100 dilution + Jurkat cell line lysate at 35 µgdeveloped using the ECL technique

Anti-PRDM6 Antibody (aa44-72, AP) - LS-C239407 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRDM6 Antibody (aa44-72, APC) - LS-C239409 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRDM6 Antibody (aa44-72, Biotin) - LS-C239410 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRDM6 Antibody (aa44-72, FITC) - LS-C239411 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRDM6 Antibody (aa44-72, Azide-free, HRP) - LS-C248544 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRDM6 Antibody (aa44-72, PE) - LS-C239412 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRDM6 Antibody (aa43-72) - LS-C324279 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRDM6 Antibody (aa448-477) - LS-C82848 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-PRDM6 Antibody (C-Terminus) - LS-C201319 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Jurkat. PRDM6 antibody dilution 1.0 ug/ml.

Anti-PRDM6 Antibody (aa44-72) - LS-C162122 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PRDM6 Antibody western blot of Jurkat cell line lysates (35 ug/lane). The PRDM6 antibody detected the PRDM6 protein (arrow).

PRDM6 Antibody - NBP1-91023 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PRDM6 Antibody [NBP1-91023] - Staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.

PRDM6 Antibody - NBP1-91022 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: PRDM6 Antibody [NBP1-91022] - Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli.

PRDM6 Antibody - NBP1-79443 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PRDM6 Antibody [NBP1-79443] - Jurkat cell lysate, concentration 0.2-1 ug/ml.

Anti-PRDM6 antibody produced in rabbit - HPA030322 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PRDM6: <B>Cat. No. HPA030322</B>: Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.

Anti-PRDM6 antibody produced in rabbit - AV51080 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV51080</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type Jurkat

PRDM6 Antibody - C-terminal region (ARP36287_P050) - ARP36287_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PRDM6 antibody - N-terminal region (ARP51080_P050) - ARP51080_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PRDM6-Antibody-N-term - AP14412a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PRDM6 Antibody (N-term) (Cat. #AP14412a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PRDM6 antibody detected the PRDM6 protein (arrow).

PRDM6 Antibody - N-terminal region (OAAB10710) - OAAB10710 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PRDM6 antibody - 70R-9062 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

PRDM6 Antibody - abx028039 from Abbexa

Host Rabbit
Clonality Polyclonal
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