Gene Symbol | PRDM6 |
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Entrez Gene | 93166 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | PR domain containing 6 |
Other Description | PR domain zinc finger protein 6|PR domain-containing protein 6|PR-domain zinc finger protein 6|putative histone-lysine N-methyltransferase PRDM6 |
Swissprots | Q9NQX0 B5MCJ4 Q9NQW9 |
Accessions | Q9NQX0 AF272898 AAF78078 AF272899 AAF78079 AK297992 BAG60300 HG498412 XM_005272128 XP_005272185 XM_011543725 XP_011542027 XM_011543726 XP_011542028 XR_948304 XR_948305 NM_001136239 NP_001129711 |
Function | Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. |
PRDM6 CRISPR/Cas9 KO Plasmid (h) - sc-406414 from Santa Cruz Biotechnology
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PRDM6 HDR Plasmid (h) - sc-406414-HDR from Santa Cruz Biotechnology
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PRDM6 Double Nickase Plasmid (h) - sc-406414-NIC from Santa Cruz Biotechnology
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PRDM6 Double Nickase Plasmid (h2) - sc-406414-NIC-2 from Santa Cruz Biotechnology
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PRDM6 CRISPR Activation Plasmid (h) - sc-406414-ACT from Santa Cruz Biotechnology
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PRDM6 CRISPR Activation Plasmid (h2) - sc-406414-ACT-2 from Santa Cruz Biotechnology
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PRDM6 Lentiviral Activation Particles (h) - sc-406414-LAC from Santa Cruz Biotechnology
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PRDM6 Lentiviral Activation Particles (h2) - sc-406414-LAC-2 from Santa Cruz Biotechnology
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PRDM6 siRNA (h) - sc-92055 from Santa Cruz Biotechnology
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PRDM6 shRNA Plasmid (h) - sc-92055-SH from Santa Cruz Biotechnology
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PRDM6 shRNA (h) Lentiviral Particles - sc-92055-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU158041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17378 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17378 from Sigma-Aldrich
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PRDM6 siRNA (Human) - CRJ4194 from Cohesion Biosciences
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shRNA set against Human PRDM6 (NM_001136239.1) - SHH382260 from Creative biogene
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Human PRDM6 siRNA - orb274695 from Biorbyt
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PRDM6 shRNA Plasmid (Human) - CHJ4194 from Cohesion Biosciences
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PRDM6 miRNA 3'UTR clone - MiUTR3H-15765 from Creative biogene
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