PRDM6

Gene Symbol	PRDM6
Entrez Gene	93166
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	PR domain containing 6
Other Description	PR domain zinc finger protein 6|PR domain-containing protein 6|PR-domain zinc finger protein 6|putative histone-lysine N-methyltransferase PRDM6
Swissprots	Q9NQX0 B5MCJ4 Q9NQW9
Accessions	Q9NQX0 AF272898 AAF78078 AF272899 AAF78079 AK297992 BAG60300 HG498412 XM_005272128 XP_005272185 XM_011543725 XP_011542027 XM_011543726 XP_011542028 XR_948304 XR_948305 NM_001136239 NP_001129711
Function	Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRDM6 Antibody Blocking Peptide - LS-E3260 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRDM6 Antibody Blocking Peptide - LS-E18402 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRDM6-Antibody-N-term-Blocking-Peptide - BP14412a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRDM6 Blocking Peptide - 33R-8519 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Recombinant Human Putative histone-lysine N-methyltransferase PRDM6(PRDM6) - CSB-YP882078HU CSB-EP882078HU CSB-BP882078HU CSB-MP882078HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PRDM6 Protein - abx163288 from Abbexa Category Protein Species Human, Mouse

PRDM6 Protein - NBP1-91023PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

PRDM6 Recombinant Protein Antigen - NBP1-91022PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant PRDM6 protein - 31495 from ActiveMotif Category Protein Prices $395.00 Sizes 20 µg Source Baculovirus Species Human

PRDM6-PFM3-Antibody-Blocking-peptide - BP1206a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRDM6 Peptide, Human - M34GP12355H from Creative Peptides Category Peptide Source Synthetic. Species Human

Putative histone-lysine N-methyltransferase PRDM6 (PRDM6), Recombinant Protein - MBS1314288 from MyBioSource Category Protein Prices $1,840.00, $1,995.00, $2,180.00, $2,295.00, $2,490.00, $2,495.00, $2,880.00, $3,090.00, $3,630.00, $4,535.00 Sizes 50 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 100 µg (Baculovirus), 1 mg (E-Coli), 50 µg (Mammalian-Cell), 1 mg (Yeast), 100 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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