| Gene Symbol |
HNRNPDL
|
| Entrez Gene |
9987
|
| Alt Symbol |
HNRNP, HNRPDL, JKTBP, JKTBP2, LGMD1G, laAUF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heterogeneous nuclear ribonucleoprotein D-like
|
| Other Description |
A+U-rich element RNA binding factor|AU-rich element RNA-binding factor|JKT41-binding protein|hnRNP D-like|hnRNP DL|protein laAUF1
|
| Swissprots |
O14979 Q96S43 Q7KZ74 Q7KZ75 Q6SPF2 Q96IM0
|
| Accessions |
AAY40914 BAA75239 BAA75240 CBF67589 CBU92463 EAX05885 EAX05886 EAX05887 EAX05888 EAX05889 EAX05890 EAX05891 O14979 AB017019 BAA75241 AB066484 BAB62188 AK057480 AK294683 BAG57844 AK300122 BAG61914 AY453824 AAR17782 BC007392 AAH07392 BC011714 AAH11714 BC018961 BC071944 AAH71944 CK300994 CR407623 CAG28551 D89092 BAA24361 D89678 BAA22860 DQ892871 ABM83797 DQ896119 ABM87118 X75683 NM_001207000 NP_001193929 NM_031372 NP_112740 NR_003249 NM_005463
|
| Function |
Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. {ECO:0000250, ECO:0000269|PubMed:9538234}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner.
|
| Tissue Specificity |
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells. {ECO:0000269|PubMed:10072754, ECO:0000269|PubMed:9538234}.
|