PLEKHG5

Gene Symbol	PLEKHG5
Entrez Gene	57449
Alt Symbol	CMTRIC, DSMA4, GEF720, Syx, Tech
Species	Human
Gene Type	protein-coding
Description	pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Other Description	NFkB activating protein|PH domain-containing family G member 5|guanine nucleotide exchange factor 720|novel PH domain-containing protein|pleckstrin homology domain containing family G member 5|pleckstrin homology domain-containing family G member 5|synectin-binding guanine exchange factor
Swissprots	Q5T8W5 Q5T8W9 B3KU07 O94827 Q6ZNM0 Q5SY17 F5H1I0 B7Z5X2 B7Z2M3 Q7Z436 Q86YD8 Q96BS1 F5GZ21
Accessions	CAI22159 EAW71539 O94827 AB018263 BAA34440 AB097001 BAC77354 AK024676 AK091201 BAG52304 AK096347 BAG53269 AK125550 AK128021 AK131074 BAC85124 AK294875 BAH11909 AK299523 BAH13058 AK301239 BAH13439 BC015231 AAH15231 BC036671 BC042606 BF033726 BG698980 BQ185626 DA091930 DA100291 DA126163 DB093234 DB225012 NM_001042663 NP_001036128 NM_001042664 NP_001036129 NM_001042665 NP_001036130 NM_001265592 NP_001252521 NM_001265593 NP_001252522 NM_001265594 NP_001252523 NM_020631 NP_065682 NM_198681 NP_941374
Function	Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. {ECO:0000269|PubMed:11704860, ECO:0000269|PubMed:12761501}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell junction {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Predominantly cytoplasmic, however when cells are stimulated found in perinuclear regions. Localized at cell-cell junctions in quiescent endothelial cells, it relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250}.
Tissue Specificity	Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines. {ECO:0000269|PubMed:11704860, ECO:0000269|PubMed:16467373, ECO:0000269|PubMed:9872452}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PLEKHG5 (E-14) - sc-165253 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PLEKHG5 (N-14) - sc-165254 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PLEKHG5 (N-15) - sc-130100 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 antibody - ab151070 from Abcam Prices $443.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 antibody - ab130599 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 antibody - ab58857 from Abcam Prices $370.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 antibody - ab57441 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-PLEKHG5 Antibody (N-Terminus) - LS-C91982 from LifeSpan Bioscience Prices $575.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 Antibody (N-Terminus) - LS-C144666 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 Antibody (aa175-202, FITC) - LS-C266540 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 Antibody (aa175-202, Azide-free, HRP) - LS-C266542 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 Antibody (aa175-202, PE) - LS-C266543 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 Antibody (aa175-202, AP) - LS-C284639 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 Antibody (aa175-202, Biotin) - LS-C284641 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 Antibody (aa175-202, APC) - LS-C284640 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 Antibody (aa174-202) - LS-C324104 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 Antibody (aa896-996, Azide-free) - LS-C328272 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-PLEKHG5 Antibody (aa175-202) - LS-C158680 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PLEKHG5 Antibody (clone 5A9) - LS-C133796 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5A9

PLEKHG5 Antibody (5A9) - H00057449-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5A9

PLEKHG5 Antibody - NBP2-13774 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PLEKHG5 Antibody - NB100-57404 from Novus Biologicals Prices $329.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

ANTI-PLEKHG5 (N-TERM) antibody produced in rabbit - SAB1304488 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Monoclonal Anti-PLEKHG5 antibody produced in mouse - WH0057449M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5A9

Anti-PLEKHG5 antibody produced in rabbit - HPA049570 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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