| Gene Symbol |
PLEKHG5
|
| Entrez Gene |
57449
|
| Alt Symbol |
CMTRIC, DSMA4, GEF720, Syx, Tech
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
|
| Other Description |
NFkB activating protein|PH domain-containing family G member 5|guanine nucleotide exchange factor 720|novel PH domain-containing protein|pleckstrin homology domain containing family G member 5|pleckstrin homology domain-containing family G member 5|synectin-binding guanine exchange factor
|
| Swissprots |
Q5T8W5 Q5T8W9 B3KU07 O94827 Q6ZNM0 Q5SY17 F5H1I0 B7Z5X2 B7Z2M3 Q7Z436 Q86YD8 Q96BS1 F5GZ21
|
| Accessions |
CAI22159 EAW71539 O94827 AB018263 BAA34440 AB097001 BAC77354 AK024676 AK091201 BAG52304 AK096347 BAG53269 AK125550 AK128021 AK131074 BAC85124 AK294875 BAH11909 AK299523 BAH13058 AK301239 BAH13439 BC015231 AAH15231 BC036671 BC042606 BF033726 BG698980 BQ185626 DA091930 DA100291 DA126163 DB093234 DB225012 NM_001042663 NP_001036128 NM_001042664 NP_001036129 NM_001042665 NP_001036130 NM_001265592 NP_001252521 NM_001265593 NP_001252522 NM_001265594 NP_001252523 NM_020631 NP_065682 NM_198681 NP_941374
|
| Function |
Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. {ECO:0000269|PubMed:11704860, ECO:0000269|PubMed:12761501}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell junction {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Predominantly cytoplasmic, however when cells are stimulated found in perinuclear regions. Localized at cell-cell junctions in quiescent endothelial cells, it relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines. {ECO:0000269|PubMed:11704860, ECO:0000269|PubMed:16467373, ECO:0000269|PubMed:9872452}.
|