PLEKHG5

Gene Symbol PLEKHG5
Entrez Gene 57449
Alt Symbol CMTRIC, DSMA4, GEF720, Syx, Tech
Species Human
Gene Type protein-coding
Description pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Other Description NFkB activating protein|PH domain-containing family G member 5|guanine nucleotide exchange factor 720|novel PH domain-containing protein|pleckstrin homology domain containing family G member 5|pleckstrin homology domain-containing family G member 5|synectin-binding guanine exchange factor
Swissprots Q5T8W5 Q5T8W9 B3KU07 O94827 Q6ZNM0 Q5SY17 F5H1I0 B7Z5X2 B7Z2M3 Q7Z436 Q86YD8 Q96BS1 F5GZ21
Accessions CAI22159 EAW71539 O94827 AB018263 BAA34440 AB097001 BAC77354 AK024676 AK091201 BAG52304 AK096347 BAG53269 AK125550 AK128021 AK131074 BAC85124 AK294875 BAH11909 AK299523 BAH13058 AK301239 BAH13439 BC015231 AAH15231 BC036671 BC042606 BF033726 BG698980 BQ185626 DA091930 DA100291 DA126163 DB093234 DB225012 NM_001042663 NP_001036128 NM_001042664 NP_001036129 NM_001042665 NP_001036130 NM_001265592 NP_001252521 NM_001265593 NP_001252522 NM_001265594 NP_001252523 NM_020631 NP_065682 NM_198681 NP_941374
Function Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. {ECO:0000269|PubMed:11704860, ECO:0000269|PubMed:12761501}.
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell junction {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Predominantly cytoplasmic, however when cells are stimulated found in perinuclear regions. Localized at cell-cell junctions in quiescent endothelial cells, it relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250}.
Tissue Specificity Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines. {ECO:0000269|PubMed:11704860, ECO:0000269|PubMed:16467373, ECO:0000269|PubMed:9872452}.

PLEKHG5 CRISPR/Cas9 KO Plasmid (h) - sc-418543 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHG5 HDR Plasmid (h) - sc-418543-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHG5 Double Nickase Plasmid (h) - sc-418543-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHG5 Double Nickase Plasmid (h2) - sc-418543-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHG5 CRISPR Activation Plasmid (h) - sc-418543-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHG5 CRISPR Activation Plasmid (h2) - sc-418543-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHG5 Lentiviral Activation Particles (h) - sc-418543-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHG5 Lentiviral Activation Particles (h2) - sc-418543-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHG5 siRNA (h) - sc-88767 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLEKHG5 shRNA Plasmid (h) - sc-88767-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLEKHG5 shRNA (h) Lentiviral Particles - sc-88767-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLEKHG5 RNAi - H00057449-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

PLEKHG5 RNAi - H00057449-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

PLEKHG5 RNAi - H00057449-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU118041 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16964 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16964 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PLEKHG5 siRNA (Human) - CRJ1446 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PLEKHG5 RNAi - H00057449-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

PLEKHG5 RNAi - H00057449-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PLEKHG5 (NM_020631.4) - SHH377656 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PLEKHG5(NM_001042663.1) - SHR122232 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PLEKHG5(NM_001042664.1) - SHR122268 from Creative biogene

Category siRNA
Species Reactivities Human

PLEKHG5 shRNA Plasmid (Human) - CHJ1446 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PLEKHG5 miRNA 3'UTR clone - MiUTR1H-08002 from Creative biogene

Species Reactivities Human
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