| Gene Symbol |
GRHL1
|
| Entrez Gene |
29841
|
| Alt Symbol |
LBP32, MGR, NH32, TFCP2L2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
grainyhead-like 1 (Drosophila)
|
| Other Description |
LBP protein 32|grainyhead-like protein 1 homolog|mammalian grainyhead|transcription factor CP2-like 2|transcription factor LBP-32
|
| Swissprots |
Q6NWN9 Q6NWN7 B5MEC2 A6NLA4 Q9NZI5 Q6NWN8 Q8NI33 Q53T93 B2R7E4
|
| Accessions |
AAX93273 EAX00973 Q9NZI5 AA234992 AF198489 AAF32276 AF411210 AAM22616 AI686262 AK293855 BAH11612 AK296982 BAG59523 AK312950 BAG35791 BC063299 BC067519 AAH67519 BC067520 AAH67520 BC067521 AAH67521 BC098456 BE537504 BF573452 CB048030 CB960104 CD559574 DA860769 XM_005246159 XP_005246216 XM_006711882 XP_006711945 XM_006711884 XP_006711947 XM_011510343 XP_011508645 XM_011510344 XP_011508646 NM_198182 NP_937825
|
| Function |
Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed (PubMed:12175488). {ECO:0000250|UniProtKB:Q921D9, ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:18288204}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18288204}.
|
| Tissue Specificity |
Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non- steroidogenic cells. {ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:12175488}.
|