| Gene Symbol |
CD180
|
| Entrez Gene |
4064
|
| Alt Symbol |
LY64, Ly78, RP105
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD180 molecule
|
| Other Description |
CD180 antigen|lymphocyte antigen 64|lymphocyte antigen-64, radioprotective, 105kDa|radioprotective 105 kDa protein
|
| Swissprots |
Q32MM5 Q99467 B2R7Z7
|
| Accessions |
EAW51318 Q99467 AK313177 BAG35994 AL544501 AL570708 AW512119 BC109069 AAI09070 BC109070 AAI09071 BP344300 D83597 BAA12019 XM_005248504 XP_005248561 NM_005582 NP_005573
|
| Function |
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
|