Gene Symbol | CD180 |
---|---|
Entrez Gene | 4064 |
Alt Symbol | LY64, Ly78, RP105 |
Species | Human |
Gene Type | protein-coding |
Description | CD180 molecule |
Other Description | CD180 antigen|lymphocyte antigen 64|lymphocyte antigen-64, radioprotective, 105kDa|radioprotective 105 kDa protein |
Swissprots | Q32MM5 Q99467 B2R7Z7 |
Accessions | EAW51318 Q99467 AK313177 BAG35994 AL544501 AL570708 AW512119 BC109069 AAI09070 BC109070 AAI09071 BP344300 D83597 BAA12019 XM_005248504 XP_005248561 NM_005582 NP_005573 |
Function | May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells. |