RAPH1

Gene Symbol RAPH1
Entrez Gene 65059
Alt Symbol ALS2CR18, ALS2CR9, LPD, PREL-2, PREL2, RMO1, RalGDS/AF-6
Species Human
Gene Type protein-coding
Description Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Other Description amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 18|amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 9|amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein|amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein|lamellipodin|proline-rich EVH1 ligand 2|ras-associated and pleckstrin homology domains-containing protein 1
Swissprots Q9C0I2 Q96Q37 Q70E73
Accessions AAY14676 EAW70344 EAW70345 EAW70346 Q70E73 AB051468 BAB21772 AB053311 BAB69020 AB053320 AF086189 AI217860 AJ584699 CAE48361 AK022729 AK095976 AK096270 BAC04744 AY494951 AAS82582 AY523977 AAS16935 AY523978 AAS16936 BC156182 AAI56183 BC156922 AAI56923 BE967038 BU620816 CA503229 XM_005246777 XP_005246834 XM_005246779 XP_005246836 XM_006712695 XP_006712758 XM_011511646 XP_011509948 XM_011511647 XP_011509949 XM_011511648 XP_011509950 XM_011511649 XP_011509951 NM_025252 NM_203365 NP_976241 NM_213589 NP_998754
Function Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15469845}; Peripheral membrane protein {ECO:0000269|PubMed:15469845}; Cytoplasmic side {ECO:0000269|PubMed:15469845}. Cell projection, lamellipodium {ECO:0000269|PubMed:15469845}. Cell projection, filopodium {ECO:0000269|PubMed:15469845}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15469845}. Note=Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin.
Tissue Specificity Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo. Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells. {ECO:0000269|PubMed:15469845, ECO:0000269|PubMed:15609301}.

Lamellipodin (E-12) - sc-67603 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Lamellipodin (E-12): sc-67603. Western blot analysis of Lamellipodin expression in NIH/3T3 whole cell lysate.

Lamellipodin (A-8) - sc-377492 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lamellipodin (A-8): sc-377492. Western blot analysis of Lamellipodin expression in MG-63 whole cell lysate.

Lamellipodin (H-150) - sc-68380 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Lamellipodin (H-150): sc-68380. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic and membrane staining of cells in glomeruli and cytoplasmic staining of cells in tubules.

Lamellipodin (H-5) - sc-390050 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lamellipodin (H-5): sc-390050. Western blot analysis of Lamellipodin expression in MG-63 whole cell lysate.

Anti-RAPH1 antibody - ab121619 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining of Human cell line U-2 OS shows positivity in nucleus, plasma membrane and cytoplasm. Recommended concentration of ab121619 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Anti-RAPH1 antibody - ab121512 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab121512 at 1/15 dilution staining RAPH1 in Paraffin-embedded Human Skin tissue by Immunohistochemistry.

Anti-RAPH1 Antibody - LS-C342144 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

RAPH1 Antibody - NBP1-90859 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: RAPH1 Antibody [NBP1-90859] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

RAPH1 Antibody - NBP1-90860 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: RAPH1 Antibody [NBP1-90860] - Staining of human skin shows strong cytoplasmic positivity in epidermal cells.

Anti-RAPH1 antibody produced in rabbit - HPA020027 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RAPH1: <B>Cat. No. HPA020027</B>: Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

Anti-RAPH1 antibody produced in rabbit - HPA016744 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RAPH1: <B>Cat. No. HPA016744</B>: Immunohistochemical staining of human skin shows strong cytoplasmic positivity in epidermal cells.

RAPH1 Antibody - abx007760 from Abbexa

Host Rabbit
Clonality Polyclonal

RAPH1 antibody - 25750-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human liver tissue slide using 25750-1-AP( RAPH1 Antibody) at dilution of 1:50 (under 10x lens)

RAPH1 antibody - H00065059-B01P from Acris Antibodies

Prices $1,530.00
Sizes 500 µg
Host Mouse
Clonality Polyclonal

RAPH1 antibody - 25750-1-AP from Proteintech Group

Prices $279.00
Sizes con: 23 μg/150μl
Host Rabbit
Clonality Polyclonal
SKOV-3 cells were subjected to SDS PAGE followed by western blot with 25750-1-AP( RAPH1 Antibody) at dilution of 1:600

Anti-RAPH1 (aa 3-75) polyclonal antibody - DPABH-18367 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-RAPH1 (aa 1105-1248) polyclonal antibody - DPABH-19325 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-RAPH1 monoclonal antibody - DCABH-201339 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

RAPH1, Polyclonal Antibody - MBS821008 from MyBioSource

Prices $155.00, $220.00, $295.00
Sizes 30 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Anti-phospho-Lamellipodin/RAPH1 Antibody (Tyr426) - ABT279 from EMD Millipore

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Lamellipodin Antibody - ABT133 from EMD Millipore

Prices $309.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry Analysis: <br />Representative lot data. <br />Confocal fluorescent analysis of HeLa cells using Cat.ABT133 Anti-Lamellipodin and a Donkey Anti-Rabbit secondary antibody conjugated to Cy3 (Red). Actin filaments have been labeled with Alexa Fluor® 488 (Green). Nucleus is stained with DAPI (Blue). This antibody positively stains the cytoskeleton

Anti-RAPH1 Antibody - CPA3079 from Cohesion Biosciences

Prices $110.00, $220.00, $350.00
Sizes 30 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of RAPH1 expression in HepG2 (A); H9C2 (B) whole cell lysates.

RAPH1 polyclonal antibody - BS60216 from Bioworld Technology

Prices $158.00, $275.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western blot (WB) analysis of RAPH1 pAb at 1:500 dilution Lane1:HepG2 whole cell lysate Lane2:H9C2 whole cell lysate

Anti-RAPH1 Antibody (Internal) - LS-C353841 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of RAPH1 expression in HepG2 (A); H9C2 (B) whole cell lysates.

Lamellipodin antibody - AP56090PU-N from Acris Antibodies

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry Analysis: Representative lot data. Confocal fluorescent analysis of HeLa cells using Cat.AP56090PU-N Anti-Lamellipodin and a Donkey Anti-Rabbit secondary antibody conjugated to Cy3 (Red). Actin filaments have been labeled with Alexa Fluor® 488 (Green). Nucleus is stained with DAPI (Blue). This antibody positively stains the cytoskeleton
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