| Gene Symbol |
RAPH1
|
| Entrez Gene |
65059
|
| Alt Symbol |
ALS2CR18, ALS2CR9, LPD, PREL-2, PREL2, RMO1, RalGDS/AF-6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
|
| Other Description |
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 18|amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 9|amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein|amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein|lamellipodin|proline-rich EVH1 ligand 2|ras-associated and pleckstrin homology domains-containing protein 1
|
| Swissprots |
Q9C0I2 Q96Q37 Q70E73
|
| Accessions |
AAY14676 EAW70344 EAW70345 EAW70346 Q70E73 AB051468 BAB21772 AB053311 BAB69020 AB053320 AF086189 AI217860 AJ584699 CAE48361 AK022729 AK095976 AK096270 BAC04744 AY494951 AAS82582 AY523977 AAS16935 AY523978 AAS16936 BC156182 AAI56183 BC156922 AAI56923 BE967038 BU620816 CA503229 XM_005246777 XP_005246834 XM_005246779 XP_005246836 XM_006712695 XP_006712758 XM_011511646 XP_011509948 XM_011511647 XP_011509949 XM_011511648 XP_011509950 XM_011511649 XP_011509951 NM_025252 NM_203365 NP_976241 NM_213589 NP_998754
|
| Function |
Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15469845}; Peripheral membrane protein {ECO:0000269|PubMed:15469845}; Cytoplasmic side {ECO:0000269|PubMed:15469845}. Cell projection, lamellipodium {ECO:0000269|PubMed:15469845}. Cell projection, filopodium {ECO:0000269|PubMed:15469845}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15469845}. Note=Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin.
|
| Tissue Specificity |
Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo. Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells. {ECO:0000269|PubMed:15469845, ECO:0000269|PubMed:15609301}.
|