RAPH1

Gene Symbol RAPH1
Entrez Gene 65059
Alt Symbol ALS2CR18, ALS2CR9, LPD, PREL-2, PREL2, RMO1, RalGDS/AF-6
Species Human
Gene Type protein-coding
Description Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Other Description amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 18|amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 9|amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein|amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein|lamellipodin|proline-rich EVH1 ligand 2|ras-associated and pleckstrin homology domains-containing protein 1
Swissprots Q9C0I2 Q96Q37 Q70E73
Accessions AAY14676 EAW70344 EAW70345 EAW70346 Q70E73 AB051468 BAB21772 AB053311 BAB69020 AB053320 AF086189 AI217860 AJ584699 CAE48361 AK022729 AK095976 AK096270 BAC04744 AY494951 AAS82582 AY523977 AAS16935 AY523978 AAS16936 BC156182 AAI56183 BC156922 AAI56923 BE967038 BU620816 CA503229 XM_005246777 XP_005246834 XM_005246779 XP_005246836 XM_006712695 XP_006712758 XM_011511646 XP_011509948 XM_011511647 XP_011509949 XM_011511648 XP_011509950 XM_011511649 XP_011509951 NM_025252 NM_203365 NP_976241 NM_213589 NP_998754
Function Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15469845}; Peripheral membrane protein {ECO:0000269|PubMed:15469845}; Cytoplasmic side {ECO:0000269|PubMed:15469845}. Cell projection, lamellipodium {ECO:0000269|PubMed:15469845}. Cell projection, filopodium {ECO:0000269|PubMed:15469845}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15469845}. Note=Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin.
Tissue Specificity Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo. Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells. {ECO:0000269|PubMed:15469845, ECO:0000269|PubMed:15609301}.

RAPH1 Blocking Peptide - abx064273 from Abbexa

Category Peptide
Species Human, Mouse, Rat

RAPH1 fusion protein - Ag22705 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50
Source E. coli -derived, PGEX-4T
Species Human

RAPH1 Blocking Peptide - CBP3079 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (RAPH1), transcript variant 3 (transcript variant 3) - TP316153 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (RAPH1), transcript variant 3

Recombinant Human RAPH1/RAPH1 GST - CSI13799 from Cell Science

Prices $430.00
Sizes 250 μg
Species Human

RAPH1 Recombinant Protein Antigen - NBP1-90860PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

RAPH1 Recombinant Protein Antigen - NBP1-90859PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

RAPH1 Peptide, Human - M34GP12974H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1), partial, Recombinant Protein - MBS1353979 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

RAPH1 peptide - orb218942 from Biorbyt

Category Peptide
Species Human, Mouse, Rat
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