PLEKHA8

Gene Symbol	PLEKHA8
Entrez Gene	84725
Alt Symbol	FAPP2
Species	Human
Gene Type	protein-coding
Description	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Other Description	PH domain-containing family A member 8|phosphatidylinositol-four-phosphate adapter protein 2|phosphoinositol 4-phosphate adapter protein 2|pleckstrin homology domain-containing family A member 8|serologically defined breast cancer antigen NY-BR-86
Swissprots	B4DH00 Q9H8Z7 Q96JA3 Q9H274 Q9BU78 Q7Z5V8
Accessions	EAW93930 EAW93931 EAW93932 EAW93933 Q96JA3 AB073667 AF308300 AAG48267 AI168153 AI954066 AK023180 BAB14449 AK294857 BAG57961 AL832700 BC002838 AAH02838 BC053990 AAH53990 CR627312 DQ893498 ABM84424 DQ896458 ABM87457 XM_005249897 XP_005249954 XM_005249898 XP_005249955 XM_011515591 XP_011513893 XM_011515592 XP_011513894 XM_011515593 XP_011513895 XM_011515594 XP_011513896 XM_011515595 XP_011513897 XM_011515596 XP_011513898 NM_001197026 NP_001183955 NM_001197027 NP_001183956 NM_032639 NP_116028
Function	Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. {ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:16103222, ECO:0000269|PubMed:17687330}.
Subcellular Location	Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein. Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes.
Tissue Specificity	Expressed in kidney cell lines. {ECO:0000269|PubMed:15107860}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FAPP2 protein (His-DHFR tag) - ab127667 from Abcam Category Protein Prices $402.00 Sizes 50 µg Source E. coli Species Human

Human FAPP2 full length protein - ab132243 from Abcam Category Protein Source Wheat germ Species Human

Human FAPP2 peptide - ab45553 from Abcam Category Peptide Species Human

PLEKHA8 Antibody Blocking Peptide - LS-E5768 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLEKHA8 Antibody Blocking Peptide - LS-E25618 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FAPP2 Protein - H00084725-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PLEKHA8-Antibody-C-term-Blocking-Peptide - BP18305b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FAPP2/PLEKHA8 blocking peptide - GTX89754-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

FAPP2 Peptide - AC21-0449-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PLEKHA8 - H00084725-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PLEKHA8 - H00084725-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FAPP2 Peptide - 45-568P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

PLEKHA8 fusion protein - Ag7677 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PLEKHA8 fusion protein - Ag7735 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PLEKHA8, GST-tagged - PLEKHA8-1778H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Pleckstrin homology domain-containing family A member 8(PLEKHA8) - CSB-YP856957HU CSB-EP856957HU CSB-BP856957HU CSB-MP856957HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Pleckstrin homology domain-containing family A member 8 (PLEKHA8), Recombinant Protein - MBS1380328 from MyBioSource Category Protein Prices $1,310.00, $1,310.00, $1,530.00, $1,530.00, $2,155.00, $2,155.00, $2,620.00, $2,620.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

FAPP2/PLEKHA8, Peptide - MBS425227 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

PLEKHA8 Peptide, Human - M34GP11928H from Creative Peptides Category Peptide Source Synthetic. Species Human

FAPP2 Recombinant Protein Antigen - NBP2-55932PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PLEKHA8 Immunizing peptide - orb16721 from Biorbyt Category Peptide

Recombinant Human PLEKHA8 Protein, His-GST-tagged - PLEKHA8-1779H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human PLEKHA8 protein, His-tagged - PLEKHA8-1720H from Creative Biomart Category Protein Source E.coli Species Human

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