PLEKHA8

Gene Symbol PLEKHA8
Entrez Gene 84725
Alt Symbol FAPP2
Species Human
Gene Type protein-coding
Description pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Other Description PH domain-containing family A member 8|phosphatidylinositol-four-phosphate adapter protein 2|phosphoinositol 4-phosphate adapter protein 2|pleckstrin homology domain-containing family A member 8|serologically defined breast cancer antigen NY-BR-86
Swissprots B4DH00 Q9H8Z7 Q96JA3 Q9H274 Q9BU78 Q7Z5V8
Accessions EAW93930 EAW93931 EAW93932 EAW93933 Q96JA3 AB073667 AF308300 AAG48267 AI168153 AI954066 AK023180 BAB14449 AK294857 BAG57961 AL832700 BC002838 AAH02838 BC053990 AAH53990 CR627312 DQ893498 ABM84424 DQ896458 ABM87457 XM_005249897 XP_005249954 XM_005249898 XP_005249955 XM_011515591 XP_011513893 XM_011515592 XP_011513894 XM_011515593 XP_011513895 XM_011515594 XP_011513896 XM_011515595 XP_011513897 XM_011515596 XP_011513898 NM_001197026 NP_001183955 NM_001197027 NP_001183956 NM_032639 NP_116028
Function Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. {ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:16103222, ECO:0000269|PubMed:17687330}.
Subcellular Location Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein. Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes.
Tissue Specificity Expressed in kidney cell lines. {ECO:0000269|PubMed:15107860}.

FAPP2 CRISPR/Cas9 KO Plasmid (h) - sc-416286 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAPP2 HDR Plasmid (h) - sc-416286-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAPP2 Double Nickase Plasmid (h) - sc-416286-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAPP2 Double Nickase Plasmid (h2) - sc-416286-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAPP2 CRISPR Activation Plasmid (h) - sc-416286-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAPP2 CRISPR Activation Plasmid (h2) - sc-416286-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAPP2 Lentiviral Activation Particles (h) - sc-416286-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAPP2 Lentiviral Activation Particles (h2) - sc-416286-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAPP2 siRNA (h) - sc-89337 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FAPP2 shRNA Plasmid (h) - sc-89337-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FAPP2 shRNA (h) Lentiviral Particles - sc-89337-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU116251 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16953 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16953 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05627 from Sigma-Aldrich

Category miRNA

PLEKHA8 siRNA (Human) - CRJ3602 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PLEKHA8 (NM_032639.3) - SHH377532 from Creative biogene

Category siRNA
Species Reactivities Human

Human PLEKHA8 siRNA - orb274103 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PLEKHA8 shRNA Plasmid (Human) - CHJ3602 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PLEKHA8 miRNA 3'UTR clone - MiUTR3H-10126 from Creative biogene

Species Reactivities Human
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