| Gene Symbol |
SLC22A16
|
| Entrez Gene |
85413
|
| Alt Symbol |
CT2, FLIPT2, OAT6, OCT6, OKB1, dJ261K5.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 22 (organic cation/carnitine transporter), member 16
|
| Other Description |
WUGSC:RG331P03.1|carnitine transporter 2|flipt 2|fly-like putative organic ion transporter 2|fly-like putative transporter 2|organic cation transporter 6|organic cation transporter OKB1|organic cation/carnitine transporter 6|solute carrier family 22 (organic cation transporter), member 16|solute carrier family 22 member 16
|
| Swissprots |
Q8IUG8 Q5JXM1 Q96M90 Q8IZD5 O14567 Q86VW1 Q96RU0
|
| Accessions |
AAB67044 EAW48313 EAW48314 EAW48315 Q86VW1 AB055798 BAC23062 AF268892 AAK58593 AI632467 AK057306 BAB71419 AK304546 BAG65342 AY145502 AAN52928 BC012014 AAH12014 BC037247 BC047565 AAH47565 JF432782 ADZ15999 XM_005267184 XP_005267241 XM_011536204 XP_011534506 XM_011536205 XP_011534507 XM_011536206 XP_011534508 XM_011536207 XP_011534509 XM_011536208 XP_011534510 XM_011536209 XP_011534511 XM_011536210 XP_011534512 XM_011536211 XP_011534513 XM_011536212 XP_011534514 NM_033125 NP_149116
|
| Function |
High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent. {ECO:0000269|PubMed:12089149, ECO:0000269|PubMed:15963465}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:12089149}. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.
|
| Tissue Specificity |
Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase. {ECO:0000269|PubMed:12089149, ECO:0000269|PubMed:12372408, ECO:0000269|PubMed:12384147, ECO:0000269|PubMed:15963465, ECO:0000269|PubMed:17197897, ECO:0000269|PubMed:17581421}.
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