SLC22A16

Gene Symbol SLC22A16
Entrez Gene 85413
Alt Symbol CT2, FLIPT2, OAT6, OCT6, OKB1, dJ261K5.1
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic cation/carnitine transporter), member 16
Other Description WUGSC:RG331P03.1|carnitine transporter 2|flipt 2|fly-like putative organic ion transporter 2|fly-like putative transporter 2|organic cation transporter 6|organic cation transporter OKB1|organic cation/carnitine transporter 6|solute carrier family 22 (organic cation transporter), member 16|solute carrier family 22 member 16
Swissprots Q8IUG8 Q5JXM1 Q96M90 Q8IZD5 O14567 Q86VW1 Q96RU0
Accessions AAB67044 EAW48313 EAW48314 EAW48315 Q86VW1 AB055798 BAC23062 AF268892 AAK58593 AI632467 AK057306 BAB71419 AK304546 BAG65342 AY145502 AAN52928 BC012014 AAH12014 BC037247 BC047565 AAH47565 JF432782 ADZ15999 XM_005267184 XP_005267241 XM_011536204 XP_011534506 XM_011536205 XP_011534507 XM_011536206 XP_011534508 XM_011536207 XP_011534509 XM_011536208 XP_011534510 XM_011536209 XP_011534511 XM_011536210 XP_011534512 XM_011536211 XP_011534513 XM_011536212 XP_011534514 NM_033125 NP_149116
Function High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent. {ECO:0000269|PubMed:12089149, ECO:0000269|PubMed:15963465}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:12089149}. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.
Tissue Specificity Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase. {ECO:0000269|PubMed:12089149, ECO:0000269|PubMed:12372408, ECO:0000269|PubMed:12384147, ECO:0000269|PubMed:15963465, ECO:0000269|PubMed:17197897, ECO:0000269|PubMed:17581421}.

OCT6 CRISPR/Cas9 KO Plasmid (h) - sc-408651 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT6 HDR Plasmid (h) - sc-408651-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT6 Double Nickase Plasmid (h) - sc-408651-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT6 Double Nickase Plasmid (h2) - sc-408651-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT6 CRISPR Activation Plasmid (h) - sc-408651-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT6 CRISPR Activation Plasmid (h2) - sc-408651-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT6 Lentiviral Activation Particles (h) - sc-408651-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT6 Lentiviral Activation Particles (h2) - sc-408651-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT6 siRNA (h) - sc-95071 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OCT6 shRNA Plasmid (h) - sc-95071-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OCT6 shRNA (h) Lentiviral Particles - sc-95071-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SLC22A16 RNAi - H00085413-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU060011 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19460 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19460 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00651 from Sigma-Aldrich

Category miRNA

SLC22A16 siRNA (Human) - CRJ3801 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A16 - MBS8216234 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC22A16 (NM_033125.3) - SHH409076 from Creative biogene

Category siRNA
Species Reactivities Human

Human SLC22A16 siRNA - orb274302 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A16 shRNA Plasmid (Human) - CHJ3801 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC22A16 miRNA 3'UTR clone - MiUTR4H-TG08191 from Creative biogene

Species Reactivities Human
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