COMP

Gene Symbol	COMP
Entrez Gene	1311
Alt Symbol	EDM1, EPD1, MED, PSACH, THBS5
Species	Human
Gene Type	protein-coding
Description	cartilage oligomeric matrix protein
Other Description	TSP5|cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|pseudoachondroplasia (epiphyseal dysplasia 1, multiple)|thrombospondin-5
Swissprots	Q8N4T2 Q16389 Q16388 Q2NL86 P49747 O14592 B4DKJ3
Accessions	AAB35269 AAB35270 AAB86501 AAC83643 CCQ42965 EAW84735 EAW84736 EAW84737 P49747 AB086984 BAC53888 AK074508 BAC11031 AK223216 BAD96936 AK290595 BAF83284 AK296586 BAG59205 AK297798 BAG60137 AK297814 BAG60152 AU120397 BC033676 BC110847 AAI10848 BC125092 AAI25093 DQ893292 ABM84218 DQ896645 ABM87644 L32137 AAA57253 NM_000095 NP_000086
Function	May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). {ECO:0000250}.
Subcellular Location	Secreted, extracellular space, extracellular matrix.
Tissue Specificity	Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. {ECO:0000269|PubMed:16542502}.
Top Pathways	Focal adhesion, ECM-receptor interaction, Phagosome, Malaria, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human COMP / THBS5 ELISA Kit (Sandwich ELISA) - LS-F2752 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 156-10000 pg/ml

Human COMP / THBS5 ELISA Kit (Sandwich ELISA) - LS-F4320 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 1.37 ng/ml Range 156-10000 pg/ml

Mouse COMP / THBS5 ELISA Kit (Sandwich ELISA) - LS-F6076 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 156-10000 pg/ml

Rat COMP / THBS5 ELISA Kit (Sandwich ELISA) - LS-F5712 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 1.42 ng/ml Range 156-10000 pg/ml

Human COMP / THBS5 ELISA Kit (Sandwich ELISA) - LS-F11173 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.94 Range 156-10000 pg/ml

Rat COMP / THBS5 ELISA Kit (Sandwich ELISA) - LS-F11174 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 156-10000 pg/ml

Human COMP Quantikine ELISA Kit - DCMP0 from R&D Systems Category ELISA Kit Prices $519.00 Sizes 1 kit Sensitivity 0.036 ng/mL Range 0.2 - 10 ng/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma)

Human COMP DuoSet ELISA - DY3134 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 39.10 - 2,500 pg/mL

Quantikine Immunoassay Control Set 702 for Human COMP - QC66 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human COMP ELISA Kit - abx054428 from Abbexa Category ELISA Kit Sensitivity 0.1 ng/ml Range 0.6 ng/ml - 40 ng/ml

Human COMP ELISA Kit - abx151136 from Abbexa Category ELISA Kit Sensitivity 29.2 pg/ml Range 62.5 pg/ml - 4000 pg/ml

Human COMP ELISA Kit - abx056117 from Abbexa Category ELISA Kit

Cartilage Oligomeric Matrix Protein (COMP), Human, ELISA Kit - PB-0913 from ARP American Research Products Category ELISA Kit Prices $418.00 Sizes 96 t Sensitivity < 10 pg/ml Range 156pg/ml-10,000pg/ml

Cartilage oligomeric matrix protein, COMP, Human, ELISA Kit - E1197h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.94-60 ng/mL

Cartilage oligomeric protein, COMP, Human, ELISA Kit - CSB-E09138h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

Cartilage Oligomeric Matrix Protein, COMP, Human, ELISA Kit - E-EL-H0654 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Cartilage Oligomeric Matrix Protein, COMP, Mouse, ELISA Kit - E-EL-M0237 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

Cartilage Oligomeric Matrix Protein, COMP, Rat, ELISA Kit - E-EL-R0159 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

Cartilage Oligomeric Matrix Protein, COMP, Rabbit, ELISA Kit - E-EL-RB1536 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

Cartilage Oligomeric Matrix Protein, COMP, Chicken, ELISA Kit - E-EL-Ch2247 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cartilage Oligomeric Matrix Protein, COMP, Porcine, ELISA Kit - E-EL-P0826 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cartilage Oligomeric Matrix Protein, COMP, Guinea Pig, ELISA Kit - E-EL-GP1290 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

Cartilage Oligomeric Matrix Protein, COMP, Monkey, ELISA Kit - E-EL-MK1582 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human COMP ELISA Kit - HC0212 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine COMP ELISA Kit - AC0212 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

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