COMP

Gene Symbol	COMP
Entrez Gene	1311
Alt Symbol	EDM1, EPD1, MED, PSACH, THBS5
Species	Human
Gene Type	protein-coding
Description	cartilage oligomeric matrix protein
Other Description	TSP5|cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|pseudoachondroplasia (epiphyseal dysplasia 1, multiple)|thrombospondin-5
Swissprots	Q8N4T2 Q16389 Q16388 Q2NL86 P49747 O14592 B4DKJ3
Accessions	AAB35269 AAB35270 AAB86501 AAC83643 CCQ42965 EAW84735 EAW84736 EAW84737 P49747 AB086984 BAC53888 AK074508 BAC11031 AK223216 BAD96936 AK290595 BAF83284 AK296586 BAG59205 AK297798 BAG60137 AK297814 BAG60152 AU120397 BC033676 BC110847 AAI10848 BC125092 AAI25093 DQ893292 ABM84218 DQ896645 ABM87644 L32137 AAA57253 NM_000095 NP_000086
Function	May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). {ECO:0000250}.
Subcellular Location	Secreted, extracellular space, extracellular matrix.
Tissue Specificity	Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. {ECO:0000269|PubMed:16542502}.
Top Pathways	Focal adhesion, ECM-receptor interaction, Phagosome, Malaria, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human COMP full length protein - ab174082 from Abcam Category Protein Prices $357.00 Sizes 100 µg Source HEK 293 cells Species Human

COMP peptide - ab199378 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human COMP full length protein - ab104358 from Abcam Category Protein Source HEK 293 cells Species Human

Human COMP full length protein - ab124873 from Abcam Category Protein Source HEK 293 cells Species Human

Human COMP peptide - ab74523 from Abcam Category Peptide

COMP / THBS5 Antibody Blocking Peptide - LS-E8537 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COMP-Antibody-Center-Blocking-Peptide - BP6906c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human COMP, CF - 3134-CP-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln21-Ala757 (Ala256Arg), with a C-terminal 6-His tag

Human COMP protein - orb168145 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human COMP/EPD1/THBS5 protein - orb82918 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

TSP5 Recombinant Protein - 96-196 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

COMP fusion protein - Ag4575 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Cartilage Oligomeric Matrix Protein HEK - BP001541-PRO-132 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source HEK293-derived. Species Human

Recombinant Human COMP, FLAG-tagged - COMP-26251TH from Creative Biomart Category Protein Source HEK 293 cells

Recombinant Human COMP, His tagged - COMP-674H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human COMP, GST-tagged - COMP-11451H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human COMP, His-tagged - COMP-3658H from Creative Biomart Category Protein Source CHO Species Human

Recombinant Human COMP, FLAG-tagged - COMP-3659H from Creative Biomart Category Protein Source HEK293 Species Human

COMP - PN201429 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

Recombinant Cartilage Oligomeric Matrix Protein (COMP) - RPB197Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cartilage Oligomeric Matrix Protein (COMP) - RPB197Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cartilage Oligomeric Matrix Protein (COMP) - RPB197Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cartilage Oligomeric Matrix Protein (COMP) - RPB197Mu03 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cartilage Oligomeric Matrix Protein (COMP) - RPB197Mu04 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cartilage Oligomeric Matrix Protein (COMP) - RPB197Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

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