| Gene Symbol |
COMP
|
| Entrez Gene |
1311
|
| Alt Symbol |
EDM1, EPD1, MED, PSACH, THBS5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cartilage oligomeric matrix protein
|
| Other Description |
TSP5|cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)|pseudoachondroplasia (epiphyseal dysplasia 1, multiple)|thrombospondin-5
|
| Swissprots |
Q8N4T2 Q16389 Q16388 Q2NL86 P49747 O14592 B4DKJ3
|
| Accessions |
AAB35269 AAB35270 AAB86501 AAC83643 CCQ42965 EAW84735 EAW84736 EAW84737 P49747 AB086984 BAC53888 AK074508 BAC11031 AK223216 BAD96936 AK290595 BAF83284 AK296586 BAG59205 AK297798 BAG60137 AK297814 BAG60152 AU120397 BC033676 BC110847 AAI10848 BC125092 AAI25093 DQ893292 ABM84218 DQ896645 ABM87644 L32137 AAA57253 NM_000095 NP_000086
|
| Function |
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix.
|
| Tissue Specificity |
Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. {ECO:0000269|PubMed:16542502}.
|
| Top Pathways |
Focal adhesion, ECM-receptor interaction, Phagosome, Malaria, PI3K-Akt signaling pathway
|
