TPP1

Gene Symbol TPP1
Entrez Gene 1200
Alt Symbol CLN2, GIG1, LPIC, SCAR7, TPP-1
Species Human
Gene Type protein-coding
Description tripeptidyl peptidase I
Other Description cell growth-inhibiting gene 1 protein|growth-inhibiting protein 1|lysosomal pepstatin insensitive protease|tripeptidyl aminopeptidase|tripeptidyl-peptidase 1
Swissprots Q71JP6 Q5JAK6 Q96C37 O14773 Q6UX56 Q53HT1
Accessions AAC98480 CAH05560 EAW68685 EAW68686 O14773 AF017456 AAB80725 AI023962 AK222499 BAD96219 AK222538 BAD96258 AK293518 BAG57000 AK293741 BAG57164 AK295801 BAG58620 AK299703 BAG61604 AK300998 BAG62617 AK303323 BAG64389 AK312388 BAG35305 AY268890 AAQ72732 AY358502 AAQ88866 BC014863 AAH14863 BP279860 BP287220 DQ891682 ABM82608 DQ894867 ABM85793 NM_000391 NP_000382
Function Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). {ECO:0000250}.
Subcellular Location Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
Top Pathways Lysosome

CLN2 (D-11) - sc-365838 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLN2 (D-11): sc-365838. Western blot analysis of CLN2 expression in JAR whole cell lysate.

CLN2 (G-3) - sc-393961 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLN2 (G-3): sc-393961. Western blot analysis of CLN2 expression in JAR (A), CCRF-CEM (B), Hep G2 (C) and A-431 (D) whole cell lysates and rat liver tissue extract (E).

CLN2 (H-300) - sc-66836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CLN2 (H-300): sc-66836. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes and bile duct cells and cytoplasmic and nuclear staining of Kupffer cells.

CLN2 (G-16) - sc-34866 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CLN2 (G-16): sc-34866. Western blot analysis of CLN2 expression in mouse heart tissue extract.

CLN2 (L-12) - sc-34867 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CLN2 (L-12): sc-34867. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

Anti-TPP1 antibody - ab54685 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
TPP1 antibody (ab54685) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human salivary gland.

Anti-TPP1 antibody - ab88305 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-TPP1 antibody (ab88305) at 1 µg/ml + human spleen tissue lysate at 50 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-TPP1 antibody - ab130631 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TPP1 antibody (ab130631) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-TPP1 antibody [3B1] - ab117613 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3B1
Anti-TPP1 antibody [3B1] (ab117613) at 1/500 dilution + A431 cell lysate

Anti-TPP1 antibody [EPR16537] - ab195234 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16537
Immunohistochemical analysis of paraffin-embedded Human placenta tissue labeling TPP1 with ab195234 at 1/150 dilution followed by Goat Anti-Rabbit IgG H&L (HRP) (ab97051) secondary antibody at 1/500 dilution and counter-stained with Hematoxylin.(inset: negative control).Note: Cytoplasm staining on human placenta tissue was observed.

Anti-TPP1 / CLN2 Antibody (aa19-33) - LS-C3257 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TPP1 / CLN2 Antibody (aa205-222) - LS-C3258 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TPP1 / CLN2 Antibody (aa6-34, AP) - LS-C272024 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPP1 / CLN2 Antibody (aa6-34, APC) - LS-C272025 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPP1 / CLN2 Antibody (aa6-34, Biotin) - LS-C272026 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPP1 / CLN2 Antibody (aa6-34, FITC) - LS-C272027 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPP1 / CLN2 Antibody (aa6-34, PE) - LS-C272029 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPP1 / CLN2 Antibody (aa6-34, Azide-free, HRP) - LS-C272028 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPP1 / CLN2 Antibody (aa5-34) - LS-C325892 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPP1 / CLN2 Antibody (aa195-305, Azide-free) - LS-C328949 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-TPP1 / CLN2 Antibody - LS-C341677 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TPP1 / CLN2 Antibody (aa6-34) - LS-C160142 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TPP1 Antibody western blot of CEM cell line lysates (35 ug/lane). The TPP1 antibody detected the TPP1 protein (arrow).

Anti-TPP1 / CLN2 Antibody - LS-C334600 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of CEM cell line, using TPP1 antibody.

Anti-TPP1 / CLN2 Antibody (aa201-215) - LS-C102868 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
TPP1 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-TPP1 / CLN2 Antibody (aa150-200) - LS-C289770 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human TPP1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from Jurkat (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and HeLa (H; 50 ug) cells. Antibodies: Affinity purified rabbit anti-TPP1 antibody used for WB at 0.4 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. TPP1 was also immunoprecipitated by rabbit anti-TPP1 antibody BL11095, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B).
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