TPP1

Gene Symbol TPP1
Entrez Gene 1200
Alt Symbol CLN2, GIG1, LPIC, SCAR7, TPP-1
Species Human
Gene Type protein-coding
Description tripeptidyl peptidase I
Other Description cell growth-inhibiting gene 1 protein|growth-inhibiting protein 1|lysosomal pepstatin insensitive protease|tripeptidyl aminopeptidase|tripeptidyl-peptidase 1
Swissprots Q71JP6 Q5JAK6 Q96C37 O14773 Q6UX56 Q53HT1
Accessions AAC98480 CAH05560 EAW68685 EAW68686 O14773 AF017456 AAB80725 AI023962 AK222499 BAD96219 AK222538 BAD96258 AK293518 BAG57000 AK293741 BAG57164 AK295801 BAG58620 AK299703 BAG61604 AK300998 BAG62617 AK303323 BAG64389 AK312388 BAG35305 AY268890 AAQ72732 AY358502 AAQ88866 BC014863 AAH14863 BP279860 BP287220 DQ891682 ABM82608 DQ894867 ABM85793 NM_000391 NP_000382
Function Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). {ECO:0000250}.
Subcellular Location Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
Top Pathways Lysosome

TPP1-Over-expression-Lysate - LY12429a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag TPP1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TPP1 gene

TPP1 293T Cell Transient Overexpression Lysate(Denatured) - H00001200-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

TPP1 293 Cell Lysate - 400218 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Tripeptidyl-Peptidase I/TPP1 Overexpression Lysate (Denatured) - H00001200-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
TPP1 transfected lysate.

Tripeptidyl-Peptidase I/TPP1 Overexpression Lysate (Native) - NBL1-17223 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: TPP1 Overexpression Lysate (Adult Normal) [NBL1-17223] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TPP1.

TPP1 Over-expression Lysate Product - GWB-734ED4 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human TPP1 Knockdown Stable Cell Line - CSC-DC016485 from Creative biogene

Category Cell Line
Species Human
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