Gene Symbol | PRDM2 |
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Entrez Gene | 7799 |
Alt Symbol | HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2 |
Species | Human |
Gene Type | protein-coding |
Description | PR domain containing 2, with ZNF domain |
Other Description | GATA-3 binding protein G3B|GATA-3-binding protein G3B|MTE-binding protein|PR domain zinc finger protein 2|PR domain-containing protein 2|lysine N-methyltransferase 8|retinoblastoma protein-binding zinc finger protein|retinoblastoma protein-interacting zinc finger protein|zinc finger protein RIZ|zinc-finger DNA-binding protein |
Swissprots | Q13029 B1AJZ4 Q5VUL9 Q5THJ1 B5MC68 Q14550 Q13149 |
Accessions | EAW51695 EAW51696 EAW51697 EAW51698 Q13029 AB208877 BAD92114 AI651991 AK123605 AK124197 AK293725 BAG57154 AK300441 BAG62164 AK307377 AK308135 AK311678 AW444997 BC014468 BC032768 BC140012 BC172414 AAI72414 BF378912 BM008289 BU621515 BX647310 D45132 BAA08110 U17838 AAC50820 U23736 AAA87023 XM_005245998 XP_005246055 XM_011542092 XP_011540394 XM_011542093 XP_011540395 NM_001007257 NP_001007258 NM_001135610 NP_001129082 NM_012231 NP_036363 NM_015866 NP_056950 |
Function | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:14633678, ECO:0000269|PubMed:7538672, ECO:0000269|PubMed:9006946}. |
Tissue Specificity | Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3. {ECO:0000269|PubMed:8654390, ECO:0000269|PubMed:9006946}. |
RIZ (N-20) - sc-14228 from Santa Cruz Biotechnology
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RIZ (33AT1045) - sc-130256 from Santa Cruz Biotechnology
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Anti-KMT8/Riz1/Riz2 antibody - ab3790 from Abcam
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Anti-RIZ1 antibody - ab9710 from Abcam
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Anti-RIZ1 antibody [33AT1045] - ab3791 from Abcam
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Anti-RIZ1 antibody - N-terminal - ab198792 from Abcam
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Anti-PRDM2 / RIZ1 Antibody (aa1098-1115) - LS-C148877 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa1-347, clone 33AT1045, AP) - LS-C250389 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa1-347, clone 33AT1045, APC) - LS-C250390 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa1-347, clone 33AT1045, Biotin) - LS-C250392 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa1-347, clone 33AT1045, FITC) - LS-C250393 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa1-347, clone 33AT1045, Azide-free, HRP) - LS-C250394 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa1-347, clone 33AT1045, PE) - LS-C250395 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa245-573, AP) - LS-C267063 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa245-573, APC) - LS-C267064 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa245-573, PE) - LS-C267068 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa245-573, FITC) - LS-C267066 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa245-573, Azide-free, HRP) - LS-C267067 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa245-573, Biotin) - LS-C267065 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa1-347, clone 33AT1045) - LS-C319195 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (aa245-573) - LS-C324276 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (clone RIZ1723) - LS-C179711 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody - LS-C98738 from LifeSpan Bioscience
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Anti-PRDM2 / RIZ1 Antibody (clone 33AT1045) - LS-C96458 from LifeSpan Bioscience
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RIZ1 Antibody - NBP1-89644 from Novus Biologicals
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