Gene Symbol | PRDM2 |
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Entrez Gene | 7799 |
Alt Symbol | HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2 |
Species | Human |
Gene Type | protein-coding |
Description | PR domain containing 2, with ZNF domain |
Other Description | GATA-3 binding protein G3B|GATA-3-binding protein G3B|MTE-binding protein|PR domain zinc finger protein 2|PR domain-containing protein 2|lysine N-methyltransferase 8|retinoblastoma protein-binding zinc finger protein|retinoblastoma protein-interacting zinc finger protein|zinc finger protein RIZ|zinc-finger DNA-binding protein |
Swissprots | Q13029 B1AJZ4 Q5VUL9 Q5THJ1 B5MC68 Q14550 Q13149 |
Accessions | EAW51695 EAW51696 EAW51697 EAW51698 Q13029 AB208877 BAD92114 AI651991 AK123605 AK124197 AK293725 BAG57154 AK300441 BAG62164 AK307377 AK308135 AK311678 AW444997 BC014468 BC032768 BC140012 BC172414 AAI72414 BF378912 BM008289 BU621515 BX647310 D45132 BAA08110 U17838 AAC50820 U23736 AAA87023 XM_005245998 XP_005246055 XM_011542092 XP_011540394 XM_011542093 XP_011540395 NM_001007257 NP_001007258 NM_001135610 NP_001129082 NM_012231 NP_036363 NM_015866 NP_056950 |
Function | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:14633678, ECO:0000269|PubMed:7538672, ECO:0000269|PubMed:9006946}. |
Tissue Specificity | Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3. {ECO:0000269|PubMed:8654390, ECO:0000269|PubMed:9006946}. |
Active human RIZ1 protein fragment - ab79913 from Abcam
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Human RIZ1 peptide - ab23566 from Abcam
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Human RIZ1 protein fragment - ab176927 from Abcam
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RIZ1 Partial Recombinant Protein - H00007799-Q01 from Novus Biologicals
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Human PRDM2 GST tag protein - orb83492 from Biorbyt
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Human PRDM2 protein - orb83500 from Biorbyt
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PRDM2 - H00007799-Q01-10 from Acris Antibodies
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PRDM2 - H00007799-Q01-25 from Acris Antibodies
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Recombinant RIZ1 protein - 31357 from ActiveMotif
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Recombinant Human PRDM2, GST tagged - PRDM2-3342H from Creative Biomart
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Recombinant Human PRDM2, None tagged - PRDM2-3344H from Creative Biomart
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Recombinant Human PRDM2 - PRDM2-27746TH from Creative Biomart
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Human PRDM2 / RIZ1 Protein (GST Tag) - 11216-H09E-50 from Sino Biological
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Human PRDM2 / RIZ1 Protein - 11216-HNCE-100 from Sino Biological
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Recombinant Human PR domain zinc finger protein 2(PRDM2) ,partial - CSB-YP613379HU CSB-EP613379HU CSB-BP613379HU CSB-MP613379HU from Cusabio
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RIZ1 (2-200 aa) (GST-tagged), Human recombinant - 7672-50 from Biovision
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RIZ1 (2-200 aa) (GST-tagged), Human recombinant - 7672-100 from Biovision
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PRDM2 (transcript variant 4) - TP327715 from Acris Antibodies
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PR domain zinc finger protein 2 (PRDM2), partial, Recombinant Protein - MBS1288636 from MyBioSource
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Recombinant Human PRDM2 / RIZ1 Protein - PKSH031203 from Elabscience
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Recombinant Human PRDM2 / RIZ1 Protein (GST tag) - PKSH031204 from Elabscience
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Recombinant Human PRDM2 Protein, GST-tagged - PRDM2-172H from Creative Biomart
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RIZ1 Protein - NBP1-89644PEP from Novus Biologicals
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PRDM2-RIZ1-Antibody-Blocking-peptide - BP1202c from Abgent, a WuXi AppTec company
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PRDM2-RIZ1-Antibody-N-term-Blocking-peptide - BP1202a from Abgent, a WuXi AppTec company
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