PRDM2
| Gene Symbol | PRDM2 |
|---|---|
| Entrez Gene | 7799 |
| Alt Symbol | HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | PR domain containing 2, with ZNF domain |
| Other Description | GATA-3 binding protein G3B|GATA-3-binding protein G3B|MTE-binding protein|PR domain zinc finger protein 2|PR domain-containing protein 2|lysine N-methyltransferase 8|retinoblastoma protein-binding zinc finger protein|retinoblastoma protein-interacting zinc finger protein|zinc finger protein RIZ|zinc-finger DNA-binding protein |
| Swissprots | Q13029 B1AJZ4 Q5VUL9 Q5THJ1 B5MC68 Q14550 Q13149 |
| Accessions | EAW51695 EAW51696 EAW51697 EAW51698 Q13029 AB208877 BAD92114 AI651991 AK123605 AK124197 AK293725 BAG57154 AK300441 BAG62164 AK307377 AK308135 AK311678 AW444997 BC014468 BC032768 BC140012 BC172414 AAI72414 BF378912 BM008289 BU621515 BX647310 D45132 BAA08110 U17838 AAC50820 U23736 AAA87023 XM_005245998 XP_005246055 XM_011542092 XP_011540394 XM_011542093 XP_011540395 NM_001007257 NP_001007258 NM_001135610 NP_001129082 NM_012231 NP_036363 NM_015866 NP_056950 |
| Function | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:14633678, ECO:0000269|PubMed:7538672, ECO:0000269|PubMed:9006946}. |
| Tissue Specificity | Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3. {ECO:0000269|PubMed:8654390, ECO:0000269|PubMed:9006946}. |
RIZ CRISPR/Cas9 KO Plasmid (h) - sc-409199 from Santa Cruz Biotechnology
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RIZ HDR Plasmid (h) - sc-409199-HDR from Santa Cruz Biotechnology
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RIZ Double Nickase Plasmid (h) - sc-409199-NIC from Santa Cruz Biotechnology
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RIZ Double Nickase Plasmid (h2) - sc-409199-NIC-2 from Santa Cruz Biotechnology
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RIZ CRISPR Activation Plasmid (h) - sc-409199-ACT from Santa Cruz Biotechnology
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RIZ CRISPR Activation Plasmid (h2) - sc-409199-ACT-2 from Santa Cruz Biotechnology
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RIZ Lentiviral Activation Particles (h) - sc-409199-LAC from Santa Cruz Biotechnology
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RIZ Lentiviral Activation Particles (h2) - sc-409199-LAC-2 from Santa Cruz Biotechnology
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RIZ siRNA (h) - sc-106513 from Santa Cruz Biotechnology
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RIZ shRNA Plasmid (h) - sc-106513-SH from Santa Cruz Biotechnology
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RIZ shRNA (h) Lentiviral Particles - sc-106513-V from Santa Cruz Biotechnology
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RIZ1 RNAi - H00007799-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN17375 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17375 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10700 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10084 from Sigma-Aldrich
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PRDM2 siRNA (Human) - CRH5277 from Cohesion Biosciences
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RIZ1 RNAi - H00007799-R03 from Novus Biologicals
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RIZ1 RNAi - H00007799-R01 from Novus Biologicals
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shRNA set against Human PRDM2 (NM_015866.4) - SHH382224 from Creative biogene
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shRNA set against Human PRDM2(NM_001135610.1) - SHR137796 from Creative biogene
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PRDM2 shRNA Plasmid (Human) - CHH5277 from Cohesion Biosciences
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PRDM2 miRNA 3'UTR clone - MiUTR1H-08228 from Creative biogene
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PRDM2 miRNA 3'UTR clone - MiUTR3H-03939 from Creative biogene
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PRDM2 miRNA 3'UTR clone - MiUTR3H-03941 from Creative biogene
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