WAC

Gene Symbol WAC
Entrez Gene 51322
Alt Symbol BM-016, PRO1741, Wwp4
Species Human
Gene Type protein-coding
Description WW domain containing adaptor with coiled-coil
Other Description WW domain-containing adapter protein with coiled-coil
Swissprots Q96DP3 Q5VXK0 C9JBT9 A8K2A9 Q53EN9 D3DRW7 Q5VXK2 Q5JU75 Q96JI3 Q9BTA9 D3DRW5 Q5JU77 Q96FW6 Q8TCK1 D3DRW6
Accessions EAW86032 EAW86033 EAW86034 EAW86035 EAW86036 EAW86037 EAW86038 EAW86039 EAW86040 EAW86041 EAW86042 Q9BTA9 AA424883 AB058747 BAB47473 AB075491 AF116666 AAF71086 AF208858 AAF64272 AK055852 BAB71029 AK091453 AK124104 AK223600 BAD97320 AK225846 AK290174 BAF82863 AK297460 BAG59883 AL713727 CAD28517 BC004258 AAH04258 BC010356 AAH10356 BI226998 BI463901 CB143386 CN415473 JF432760 ADZ15977 XM_005252454 XP_005252511 XM_011519491 XP_011517793 XR_930491 NM_016628 NP_057712 NM_100264 NP_567822 NM_100486 NP_567823
Function Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037}.
Subcellular Location Nucleus speckle {ECO:0000250}. Nucleus {ECO:0000269|PubMed:21329877}. Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes (By similarity). {ECO:0000250}.

WAC (N-17) - sc-163517 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
WAC (N-17): sc-163517. Western blot analysis of WAC expression in HeLa nuclear extract.

Anti-WAC antibody - ab109486 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab109486 stained MCF-7 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab109486 at 5µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-WAC antibody - ab167120 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-WAC antibody (ab167120) at 1 µg/ml + Human testis tissue lysate at 15 µg

Anti-WAC antibody - ab103994 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-WAC antibody (ab103994) at 1/100 dilution + HepG2 cell lysate at 35 µg

Anti-WAC antibody - N-terminal - ab193011 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-WAC antibody - N-terminal (ab193011) at 1 µg/ml + HeLa whole cell lysate at 10 µg

Anti-WAC Antibody (aa284-313, APC) - LS-C242672 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WAC Antibody (aa284-313, AP) - LS-C242673 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WAC Antibody (aa284-313, Biotin) - LS-C242674 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WAC Antibody (aa284-313, FITC) - LS-C242675 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WAC Antibody (aa284-313, PE) - LS-C242676 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WAC Antibody (aa291-321) - LS-C326309 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WAC Antibody (aa284-313, Azide-free, HRP) - LS-C247237 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WAC Antibody (N-Terminus) - LS-C345571 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of WAC Antibody with human HeLa Whole Cell lysate.

Anti-WAC Antibody (aa284-313) - LS-C160562 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of WAC Antibody in HepG2 cell line lysates (35 ug/lane). WAC(arrow) was detected using the purified antibody.

Anti-WAC Antibody (Internal) - LS-C201071 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of WAC in mouse testis tissue with WAC antibody at 2.5 ug/ml.

WAC Antibody - NBP1-88581 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: WAC Antibody [NBP1-88581] - Staining of human hippocampus shows strong nuclear positivity in neuronal cells.

ANTI-WAC (CENTER) antibody produced in rabbit - SAB1303813 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-WAC antibody produced in rabbit - HPA036528 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-WAC: <B>Cat. No. HPA036528</B>: Immunohistochemical staining of human hippocampus shows strong nuclear positivity in neuronal cells.

Anti-WAC antibody produced in rabbit - SAB3500833 from Sigma-Aldrich

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>WAC Antibody: <B>Cat. No. SAB3500833</B>: Western blot analysis of WAC in Human testis tissue lysate with WAC antibody at 1 μg/mL.

WAC Antibody - N-terminal region (ARP59223_P050) - ARP59223_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

WAC-Antibody-Center - AP9537c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of WAC Antibody (Center) (Cat. #AP9537c) in HepG2 cell line lysates (35ug/lane). WAC(arrow) was detected using the purified Pab.

WAC Antibody - middle region (OAAB06134) - OAAB06134 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

WAC antibody - orb40237 from Biorbyt

Prices $60.00, $128.00, $383.00
Sizes 5 μg (Trial size), 80 μl (Trial size), 400 μl
Host Rabbit
Clonality Polyclonal
Western blot analysis of WAC antibody in HepG2 cell line lysates

WAC Antibody - abx034415 from Abbexa

Host Rabbit
Clonality Polyclonal

WAC (Center) antibody - AP54530PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of WAC Antibody (Center) (AP54530PU-N) in HepG2 cell line lysates (35 µg/lane). WAC(arrow) was detected using the purified Pab.
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