WAC

Gene Symbol	WAC
Entrez Gene	51322
Alt Symbol	BM-016, PRO1741, Wwp4
Species	Human
Gene Type	protein-coding
Description	WW domain containing adaptor with coiled-coil
Other Description	WW domain-containing adapter protein with coiled-coil
Swissprots	Q96DP3 Q5VXK0 C9JBT9 A8K2A9 Q53EN9 D3DRW7 Q5VXK2 Q5JU75 Q96JI3 Q9BTA9 D3DRW5 Q5JU77 Q96FW6 Q8TCK1 D3DRW6
Accessions	EAW86032 EAW86033 EAW86034 EAW86035 EAW86036 EAW86037 EAW86038 EAW86039 EAW86040 EAW86041 EAW86042 Q9BTA9 AA424883 AB058747 BAB47473 AB075491 AF116666 AAF71086 AF208858 AAF64272 AK055852 BAB71029 AK091453 AK124104 AK223600 BAD97320 AK225846 AK290174 BAF82863 AK297460 BAG59883 AL713727 CAD28517 BC004258 AAH04258 BC010356 AAH10356 BI226998 BI463901 CB143386 CN415473 JF432760 ADZ15977 XM_005252454 XP_005252511 XM_011519491 XP_011517793 XR_930491 NM_016628 NP_057712 NM_100264 NP_567822 NM_100486 NP_567823
Function	Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037}.
Subcellular Location	Nucleus speckle {ECO:0000250}. Nucleus {ECO:0000269|PubMed:21329877}. Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human WAC full length protein - ab162510 from Abcam Category Protein Source Wheat germ Species Human

WAC Antibody Blocking Peptide - LS-E31424 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

WAC Antibody Blocking Peptide - LS-E10186 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WAC Protein - H00051322-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

WAC-Antibody-Center-Blocking-Peptide - BP9537c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WAC - H00051322-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

WAC Peptide - 7293P from ProSci Category Peptide Species Human

WAC fusion protein - ag14355 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

WAC fusion protein - Ag14883 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human WW domain-containing adapter protein with coiled-coil(WAC) - CSB-YP861133HU CSB-EP861133HU CSB-BP861133HU CSB-MP861133HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

WW domain-containing adapter protein with coiled-coil(WAC) , Recombinant Protein - MBS1288179 from MyBioSource Category Protein Prices $2,455.00, $2,455.00, $2,875.00, $2,875.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

WAC Recombinant Protein Antigen - NBP1-88581PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

WAC Peptide, Human - M34GP17372H from Creative Peptides Category Peptide Source Synthetic. Species Human

WAC Recombinant Protein Antigen - NBP2-59019PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

WAC Recombinant Protein (Bacteriophage T4) (OPCA04339) - OPCA04339 from Aviva Systems Biology Category Protein

Recombinant Enterobacteria Phage T4 WAC Protein (2-487 aa), His-SUMO-tagged - WAC-2065E from Creative Biomart Category Protein Source E. coli

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