WAC

Gene Symbol WAC
Entrez Gene 51322
Alt Symbol BM-016, PRO1741, Wwp4
Species Human
Gene Type protein-coding
Description WW domain containing adaptor with coiled-coil
Other Description WW domain-containing adapter protein with coiled-coil
Swissprots Q96DP3 Q5VXK0 C9JBT9 A8K2A9 Q53EN9 D3DRW7 Q5VXK2 Q5JU75 Q96JI3 Q9BTA9 D3DRW5 Q5JU77 Q96FW6 Q8TCK1 D3DRW6
Accessions EAW86032 EAW86033 EAW86034 EAW86035 EAW86036 EAW86037 EAW86038 EAW86039 EAW86040 EAW86041 EAW86042 Q9BTA9 AA424883 AB058747 BAB47473 AB075491 AF116666 AAF71086 AF208858 AAF64272 AK055852 BAB71029 AK091453 AK124104 AK223600 BAD97320 AK225846 AK290174 BAF82863 AK297460 BAG59883 AL713727 CAD28517 BC004258 AAH04258 BC010356 AAH10356 BI226998 BI463901 CB143386 CN415473 JF432760 ADZ15977 XM_005252454 XP_005252511 XM_011519491 XP_011517793 XR_930491 NM_016628 NP_057712 NM_100264 NP_567822 NM_100486 NP_567823
Function Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037}.
Subcellular Location Nucleus speckle {ECO:0000250}. Nucleus {ECO:0000269|PubMed:21329877}. Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes (By similarity). {ECO:0000250}.

WAC 293 Cell Lysate - 406664 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

WAC Overexpression Lysate (Native) - NBL1-17771 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: WAC Overexpression Lysate (Adult Normal) [NBL1-17771] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for WAC.

WAC Over-expression Lysate Product - GWB-76350E from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human WAC Knockdown Stable Cell Line - CSC-DC017372 from Creative biogene

Category Cell Line
Species Human
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