| Gene Symbol |
NSUN2
|
| Entrez Gene |
54888
|
| Alt Symbol |
MISU, MRT5, SAKI, TRM4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NOP2/Sun RNA methyltransferase family, member 2
|
| Other Description |
5-methycytoisine methyltransferase|Myc-induced SUN-domain-containing protein|NOL1/NOP2/Sun domain family, member 2|NOP2/Sun domain family, member 2|myc-induced SUN domain-containing protein|substrate of AIM1/Aurora kinase B|tRNA (cytosine(34)-C(5))-methyltransferase|tRNA (cytosine-5-)-methyltransferase NSUN2|tRNA methyltransferase 4 homolog
|
| Swissprots |
Q08J23 G3V1R4 B4DQW2 B3KP09 Q9NXD9 Q9BVN4 B2RNR4 A8K529 Q9H858
|
| Accessions |
EAX08105 EAX08106 EAX08107 Q08J23 AB255451 BAF34150 AK000310 BAA91075 AK023994 BAB14762 AK055456 BAG51521 AK291144 BAF83833 AK298980 BAG61074 BC001041 AAH01041 BC137083 AAI37084 BF000644 BG387061 BQ689094 NM_001193455 NP_001180384 NM_017755 NP_060225 NR_037947
|
| Function |
RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity. {ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22995836}.
|
| Subcellular Location |
Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Note=Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA.
|
| Tissue Specificity |
Expressed in adult and fetal brain and in lymphoblastoid cells. {ECO:0000269|PubMed:22541559}.
|
