NSUN2

Gene Symbol NSUN2
Entrez Gene 54888
Alt Symbol MISU, MRT5, SAKI, TRM4
Species Human
Gene Type protein-coding
Description NOP2/Sun RNA methyltransferase family, member 2
Other Description 5-methycytoisine methyltransferase|Myc-induced SUN-domain-containing protein|NOL1/NOP2/Sun domain family, member 2|NOP2/Sun domain family, member 2|myc-induced SUN domain-containing protein|substrate of AIM1/Aurora kinase B|tRNA (cytosine(34)-C(5))-methyltransferase|tRNA (cytosine-5-)-methyltransferase NSUN2|tRNA methyltransferase 4 homolog
Swissprots Q08J23 G3V1R4 B4DQW2 B3KP09 Q9NXD9 Q9BVN4 B2RNR4 A8K529 Q9H858
Accessions EAX08105 EAX08106 EAX08107 Q08J23 AB255451 BAF34150 AK000310 BAA91075 AK023994 BAB14762 AK055456 BAG51521 AK291144 BAF83833 AK298980 BAG61074 BC001041 AAH01041 BC137083 AAI37084 BF000644 BG387061 BQ689094 NM_001193455 NP_001180384 NM_017755 NP_060225 NR_037947
Function RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity. {ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22995836}.
Subcellular Location Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Note=Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA.
Tissue Specificity Expressed in adult and fetal brain and in lymphoblastoid cells. {ECO:0000269|PubMed:22541559}.

NSUN2 CRISPR/Cas9 KO Plasmid (h) - sc-405097 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NSUN2 HDR Plasmid (h) - sc-405097-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NSUN2 Double Nickase Plasmid (h) - sc-405097-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NSUN2 Double Nickase Plasmid (h2) - sc-405097-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NSUN2 CRISPR Activation Plasmid (h) - sc-405097-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NSUN2 CRISPR Activation Plasmid (h2) - sc-405097-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NSUN2 Lentiviral Activation Particles (h) - sc-405097-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NSUN2 Lentiviral Activation Particles (h2) - sc-405097-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NSUN2 siRNA (h) - sc-75964 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NSUN2 shRNA Plasmid (h) - sc-75964-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NSUN2 shRNA (h) Lentiviral Particles - sc-75964-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU156811 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15538 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15538 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06125 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06125

NSUN2 siRNA (Human) - CRJ0299 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human NSUN2 siRNA - orb270800 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NSUN2 shRNA Plasmid (Human) - CHJ0299 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NSUN2 miRNA 3'UTR clone - MiUTR3H-11546 from Creative biogene

Species Reactivities Human
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