| Gene Symbol |
ACAP1
|
| Entrez Gene |
9744
|
| Alt Symbol |
CENTB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
|
| Other Description |
Arf GAP with coiled coil, ANK repeat and PH domains 1|arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1|centaurin, beta 1|centaurin-beta-1|cnt-b1
|
| Swissprots |
Q53XN9 Q15027
|
| Accessions |
EAW90209 EAW90210 Q15027 AA356620 BC018543 AAH18543 BT009788 AAP88790 D30758 BAA06418 DQ891719 ABM82645 XM_005256878 XP_005256935 XR_243574 XR_429827 NM_014716 NP_055531
|
| Function |
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17398097, ECO:0000269|PubMed:17664335, ECO:0000269|PubMed:22645133}.
|
| Subcellular Location |
Recycling endosome membrane {ECO:0000269|PubMed:16256741}; Peripheral membrane protein {ECO:0000269|PubMed:16256741}; Cytoplasmic side {ECO:0000269|PubMed:16256741}.
|
| Tissue Specificity |
Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. {ECO:0000269|PubMed:11062263}.
|
| Top Pathways |
Endocytosis
|
![Western Blot: CENTB1 Overexpression Lysate (Adult Normal) [NBL1-09094] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CENTB1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/10062_CENTB1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09094-img0002.jpg)