Gene Symbol | ACAP1 |
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Entrez Gene | 9744 |
Alt Symbol | CENTB1 |
Species | Human |
Gene Type | protein-coding |
Description | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 |
Other Description | Arf GAP with coiled coil, ANK repeat and PH domains 1|arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1|centaurin, beta 1|centaurin-beta-1|cnt-b1 |
Swissprots | Q53XN9 Q15027 |
Accessions | EAW90209 EAW90210 Q15027 AA356620 BC018543 AAH18543 BT009788 AAP88790 D30758 BAA06418 DQ891719 ABM82645 XM_005256878 XP_005256935 XR_243574 XR_429827 NM_014716 NP_055531 |
Function | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17398097, ECO:0000269|PubMed:17664335, ECO:0000269|PubMed:22645133}. |
Subcellular Location | Recycling endosome membrane {ECO:0000269|PubMed:16256741}; Peripheral membrane protein {ECO:0000269|PubMed:16256741}; Cytoplasmic side {ECO:0000269|PubMed:16256741}. |
Tissue Specificity | Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. {ECO:0000269|PubMed:11062263}. |
Top Pathways | Endocytosis |
Human CENTB1 full length protein - ab132164 from Abcam
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Human CENTB1 peptide - ab23280 from Abcam
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Human CENTB1 protein fragment - ab160635 from Abcam
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CENTB1 / ACAP1 Antibody Blocking Peptide - LS-E782 from LifeSpan Bioscience
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CENTB1 / ACAP1 Antibody Blocking Peptide - LS-E25612 from LifeSpan Bioscience
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Recombinant Human CENTB1 Protein - H00009744-P01 from Novus Biologicals
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CENTB1 Partial Recombinant Protein - H00009744-Q01 from Novus Biologicals
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ACAP1-Antibody-N-term-Blocking-peptide - BP11134a from Abgent, a WuXi AppTec company
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CENTB1 Peptide - AC21-0443-P from Abcore
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ACAP1 / CENTB1 - H00009744-P01-10 from Acris Antibodies
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ACAP1 / CENTB1 - H00009744-P01-25 from Acris Antibodies
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ACAP1 / CENTB1 - H00009744-Q01-10 from Acris Antibodies
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ACAP1 / CENTB1 - H00009744-Q01-25 from Acris Antibodies
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ACAP1 Peptide - 45-191P from ProSci
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ACAP1 fusion protein - ag14068 from Proteintech Group
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ACAP1 fusion protein - Ag14254 from Proteintech Group
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Recombinant Human Arf-GAP with coiled-coil, ANK repeat and PH domain-containing - CSB-YP622985HU CSB-EP622985HU CSB-BP622985HU CSB-MP622985HU from Cusabio
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ACAP1 / CENTB1 - TP303724 from Acris Antibodies
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Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1(ACAP1) , Recombinant Protein - MBS1356972 from MyBioSource
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CENTB1/ACAP1, Peptide - MBS425537 from MyBioSource
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CENTB1 Protein - NBP2-14256PEP from Novus Biologicals
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CENTB1 Recombinant Protein Antigen - NBP2-55692PEP from Novus Biologicals
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ACAP1 Immunizing peptide - orb17568 from Biorbyt
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