RAF1
| Gene Symbol | RAF1 |
|---|---|
| Entrez Gene | 5894 |
| Alt Symbol | CMD1NN, CRAF, NS5, Raf-1, c-Raf |
| Species | Human |
| Gene Type | protein-coding |
| Description | Raf-1 proto-oncogene, serine/threonine kinase |
| Other Description | C-Raf proto-oncogene, serine/threonine kinase|Oncogene RAF1|RAF proto-oncogene serine/threonine-protein kinase|proto-oncogene c-RAF|raf proto-oncogene serine/threonine protein kinase|v-raf-1 murine leukemia viral oncogene homolog 1 |
| Swissprots | Q9UC20 B0LPH8 P04049 Q15278 B2R5N3 |
| Accessions | AAA60247 AAP03432 ABY87557 AGC09606 CAD86886 CBX55729 CDL93489 EAW64134 EAW64135 P04049 AK226028 AK303561 BAG64584 AK303920 BAG64848 AK312248 BAG35180 BC018119 AAH18119 BQ221862 BU683389 BX648063 DC342671 X03484 CAA27204 XM_005265355 XP_005265412 XM_005265357 XP_005265414 XM_005265358 XP_005265415 XM_005265359 XP_005265416 XM_005265360 XP_005265417 XM_011533974 XP_011532276 XM_011533975 XP_011532277 NM_002880 NP_002871 |
| Function | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2- antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in mot |
| Subcellular Location | Cytoplasm. Cell membrane. Mitochondrion. Nucleus. Note=Colocalizes with RGS14 and BRAF in both the cytoplasm and membranes. Phosphorylation at Ser-259 impairs its membrane accumulation. Recruited to the cell membrane by the active Ras protein. Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for its mitochondrial localization. Retinoic acid- induced Ser-621 phosphorylated form of RAF1 is predominantly localized at the nucleus. |
| Tissue Specificity | In skeletal muscle, isoform 1 is more abundant than isoform 2. {ECO:0000269|PubMed:1886707}. |
| Top Pathways | VEGF signaling pathway, Focal adhesion, Gap junction, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway |
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