RAF1

Gene Symbol	RAF1
Entrez Gene	5894
Alt Symbol	CMD1NN, CRAF, NS5, Raf-1, c-Raf
Species	Human
Gene Type	protein-coding
Description	Raf-1 proto-oncogene, serine/threonine kinase
Other Description	C-Raf proto-oncogene, serine/threonine kinase|Oncogene RAF1|RAF proto-oncogene serine/threonine-protein kinase|proto-oncogene c-RAF|raf proto-oncogene serine/threonine protein kinase|v-raf-1 murine leukemia viral oncogene homolog 1
Swissprots	Q9UC20 B0LPH8 P04049 Q15278 B2R5N3
Accessions	AAA60247 AAP03432 ABY87557 AGC09606 CAD86886 CBX55729 CDL93489 EAW64134 EAW64135 P04049 AK226028 AK303561 BAG64584 AK303920 BAG64848 AK312248 BAG35180 BC018119 AAH18119 BQ221862 BU683389 BX648063 DC342671 X03484 CAA27204 XM_005265355 XP_005265412 XM_005265357 XP_005265414 XM_005265358 XP_005265415 XM_005265359 XP_005265416 XM_005265360 XP_005265417 XM_011533974 XP_011532276 XM_011533975 XP_011532277 NM_002880 NP_002871
Function	Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2- antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in mot
Subcellular Location	Cytoplasm. Cell membrane. Mitochondrion. Nucleus. Note=Colocalizes with RGS14 and BRAF in both the cytoplasm and membranes. Phosphorylation at Ser-259 impairs its membrane accumulation. Recruited to the cell membrane by the active Ras protein. Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for its mitochondrial localization. Retinoic acid- induced Ser-621 phosphorylated form of RAF1 is predominantly localized at the nucleus.
Tissue Specificity	In skeletal muscle, isoform 1 is more abundant than isoform 2. {ECO:0000269|PubMed:1886707}.
Top Pathways	VEGF signaling pathway, Focal adhesion, Gap junction, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active Raf1 (mutated F341 Q) protein fragment - ab55721 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells

Active Raf1 protein fragment - ab62292 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells

Human Raf1 protein fragment - ab90536 from Abcam Category Protein Source E. coli Species Human

Raf1 peptide - ab53345 from Abcam Category Peptide

RAF1 / RAF Antibody Blocking Peptide - LS-E3140 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E30939 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E7335 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E7348 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E7394 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E7405 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E7349 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E7353 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E7382 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E7380 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E7386 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAF1 / RAF Antibody Blocking Peptide - LS-E9287 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Raf-1 Recombinant Protein - H00005894-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Raf-1 Partial Recombinant Protein - H00005894-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Raf-1 Recombinant Protein - P4210 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant Human Raf-1 Protein - P4836 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

Raf-1 Peptide - NBP1-76270PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Recombinant Human Raf-1 Protein - NBP1-99475 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells) Species Human

Raf-1 Peptide - P1609 from Novus Biologicals Category Peptide Species Human

Raf-1 Peptide - P1644 from Novus Biologicals Category Peptide Species Human

Raf-1 Peptide - P2839 from Novus Biologicals Category Peptide Species Human

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