| Gene Symbol |
CYP2A13
|
| Entrez Gene |
1553
|
| Alt Symbol |
CPAD, CYP2A, CYPIIA13
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 2, subfamily A, polypeptide 13
|
| Other Description |
cytochrome P450 2A13|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13
|
| Swissprots |
Q6R569 Q16696 Q9H2X2 Q6R570 Q53YR8
|
| Accessions |
AAB40519 EAW57016 Q16696 AF209774 AAG35775 AY513604 AAR90935 AY513605 AAR90936 AY513606 AAR90937 AY513607 AAR90938 AY513608 AAR90939 AY513609 AAR90940 BC148422 AAI48423 BC153000 AAI53001 BM975825 NM_000766 NP_000757
|
| Function |
Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2'-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. {ECO:0000269|PubMed:18779312}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle. {ECO:0000269|PubMed:11016631}.
|
| Top Pathways |
Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450
|