Gene Symbol | CYP2A13 |
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Entrez Gene | 1553 |
Alt Symbol | CPAD, CYP2A, CYPIIA13 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 2, subfamily A, polypeptide 13 |
Other Description | cytochrome P450 2A13|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13 |
Swissprots | Q6R569 Q16696 Q9H2X2 Q6R570 Q53YR8 |
Accessions | AAB40519 EAW57016 Q16696 AF209774 AAG35775 AY513604 AAR90935 AY513605 AAR90936 AY513606 AAR90937 AY513607 AAR90938 AY513608 AAR90939 AY513609 AAR90940 BC148422 AAI48423 BC153000 AAI53001 BM975825 NM_000766 NP_000757 |
Function | Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2'-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. {ECO:0000269|PubMed:18779312}. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity | Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle. {ECO:0000269|PubMed:11016631}. |
Top Pathways | Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450 |
CYP2A13 CRISPR/Cas9 KO Plasmid (h) - sc-403450 from Santa Cruz Biotechnology
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CYP2A13 HDR Plasmid (h) - sc-403450-HDR from Santa Cruz Biotechnology
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CYP2A13 Double Nickase Plasmid (h) - sc-403450-NIC from Santa Cruz Biotechnology
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CYP2A13 Double Nickase Plasmid (h2) - sc-403450-NIC-2 from Santa Cruz Biotechnology
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CYP2A CRISPR Activation Plasmid (h) - sc-403450-ACT from Santa Cruz Biotechnology
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CYP2A13 CRISPR Activation Plasmid (h2) - sc-403450-ACT-2 from Santa Cruz Biotechnology
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CYP2A13 Lentiviral Activation Particles (h) - sc-403450-LAC from Santa Cruz Biotechnology
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CYP2A13 Lentiviral Activation Particles (h2) - sc-403450-LAC-2 from Santa Cruz Biotechnology
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CYP2A13 siRNA (h) - sc-41487 from Santa Cruz Biotechnology
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CYP2A13 shRNA Plasmid (h) - sc-41487-SH from Santa Cruz Biotechnology
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CYP2A13 shRNA (h) Lentiviral Particles - sc-41487-V from Santa Cruz Biotechnology
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CYP2A13 RNAi - H00001553-R01 from Novus Biologicals
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MISSION® esiRNA - EHU152841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1799 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1799 from Sigma-Aldrich
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CYP2A13 siRNA (Human) - CRH1096 from Cohesion Biosciences
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CYP2A13 - MBS8205675 from MyBioSource
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CYP2A13 CRISPR/Cas9 KO Plasmid (h2) - sc-403450-KO-2 from Santa Cruz Biotechnology
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CYP2A13 HDR Plasmid (h2) - sc-403450-HDR-2 from Santa Cruz Biotechnology
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Human CYP2A13 siRNA - orb261598 from Biorbyt
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CYP2A13 shRNA Plasmid (Human) - CHH1096 from Cohesion Biosciences
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CYP2A13 miRNA 3'UTR clone - MiUTR3H-09703 from Creative biogene
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