| Gene Symbol |
ERCC4
|
| Entrez Gene |
2072
|
| Alt Symbol |
ERCC11, FANCQ, RAD1, XPF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
excision repair cross-complementation group 4
|
| Other Description |
DNA excision repair protein ERCC-4|DNA repair endonuclease XPF|DNA repair protein complementing XP-F cells|excision repair cross-complementing rodent repair deficiency, complementation group 4|excision-repair, complementing defective, in Chinese hamster|xeroderma pigmentosum group F-complementing protein|xeroderma pigmentosum, complementation group F
|
| Swissprots |
Q8TD83 A5PKV6 Q92889 O00140 A8K111
|
| Accessions |
AAB50174 AAL91593 EAW85117 EAW85118 Q92889 AI470593 AK289726 BAF82415 AK301930 BAG63350 AK308341 BC020741 AAH20741 BC142631 AAI42632 BC160102 AAI60102 U64315 AAB07689 XM_011522424 XP_011520726 XM_011522425 XP_011520727 XM_011522426 XP_011520728 XM_011522427 XP_011520729 XR_932805 NM_005236 NP_005227
|
| Function |
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. {ECO:0000269|PubMed:19596235}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Top Pathways |
Nucleotide excision repair, Fanconi anemia pathway
|
![Western Blot: XPF Overexpression Lysate (Adult Normal) [NBL1-10322] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for XPF.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12279_XPF%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-10322-img0002.jpg)